Antiretroviral treatment-associated tuberculosis in a prospective cohort of HIV-infected patients starting ART

William Worodria, Marguerite Massinga-Loembe, Harriet Mayanja-Kizza, Jane Namaganda, Andrew Kambugu, Yukari C Manabe, Luc Kestens, Robert Colebunders

Research output: Contribution to journalArticle

Abstract

Commencement of antiretroviral treatment (ART) in severely immunosuppressed HIV-infected persons is associated with unmasking of subclinical disease. The subset of patients that are diagnosed with tuberculosis (TB) disease while on ART have been classified as ART-associated TB. Few studies have reported the incidence of ART-associated TB and unmasking TB-IRIS according to the International Network for the Study of HIV-Associated IRIS (INSHI) consensus definition. To determine the incidence and predictors of ART-associated TB, we screened 219 patients commencing ART at the Infectious Diseases Clinic in Kampala, Uganda for TB by symptoms, sputum microscopy, and chest X-rays and followed them for one year. Fourteen (6.4%) patients were diagnosed with TB during followup. Eight (3.8%) patients had ART-associated TB (incidence rate of 4.3 per 100 person years); of these, three patients fulfilled INSHI criteria for unmasking TB-associated IRIS (incidence rate of 1.6 per 100 person years). A body mass index of less than 18.5kg/m2 BMI (HR 5.85 95% CI 1.24-27.46, P =.025) and a C-reactive protein greater than 5mg/L (HR 8.23 95% CI 1.36-38.33, P =.020) were risk factors for ART-associated TB at multivariate analysis. In conclusion, with systematic TB screening (including culture and chest X-ray), the incidence of ART-associated TB is relatively low in settings with high HIV and TB prevalence.

Original languageEnglish (US)
Article number758350
JournalClinical and Developmental Immunology
Volume2011
DOIs
StatePublished - 2011

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Tuberculosis
HIV
Therapeutics
Incidence
Thorax
X-Rays
Uganda
Sputum
C-Reactive Protein
Communicable Diseases
Microscopy
Body Mass Index
Multivariate Analysis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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Antiretroviral treatment-associated tuberculosis in a prospective cohort of HIV-infected patients starting ART. / Worodria, William; Massinga-Loembe, Marguerite; Mayanja-Kizza, Harriet; Namaganda, Jane; Kambugu, Andrew; Manabe, Yukari C; Kestens, Luc; Colebunders, Robert.

In: Clinical and Developmental Immunology, Vol. 2011, 758350, 2011.

Research output: Contribution to journalArticle

Worodria, W, Massinga-Loembe, M, Mayanja-Kizza, H, Namaganda, J, Kambugu, A, Manabe, YC, Kestens, L & Colebunders, R 2011, 'Antiretroviral treatment-associated tuberculosis in a prospective cohort of HIV-infected patients starting ART', Clinical and Developmental Immunology, vol. 2011, 758350. https://doi.org/10.1155/2011/758350
Worodria, William ; Massinga-Loembe, Marguerite ; Mayanja-Kizza, Harriet ; Namaganda, Jane ; Kambugu, Andrew ; Manabe, Yukari C ; Kestens, Luc ; Colebunders, Robert. / Antiretroviral treatment-associated tuberculosis in a prospective cohort of HIV-infected patients starting ART. In: Clinical and Developmental Immunology. 2011 ; Vol. 2011.
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abstract = "Commencement of antiretroviral treatment (ART) in severely immunosuppressed HIV-infected persons is associated with unmasking of subclinical disease. The subset of patients that are diagnosed with tuberculosis (TB) disease while on ART have been classified as ART-associated TB. Few studies have reported the incidence of ART-associated TB and unmasking TB-IRIS according to the International Network for the Study of HIV-Associated IRIS (INSHI) consensus definition. To determine the incidence and predictors of ART-associated TB, we screened 219 patients commencing ART at the Infectious Diseases Clinic in Kampala, Uganda for TB by symptoms, sputum microscopy, and chest X-rays and followed them for one year. Fourteen (6.4{\%}) patients were diagnosed with TB during followup. Eight (3.8{\%}) patients had ART-associated TB (incidence rate of 4.3 per 100 person years); of these, three patients fulfilled INSHI criteria for unmasking TB-associated IRIS (incidence rate of 1.6 per 100 person years). A body mass index of less than 18.5kg/m2 BMI (HR 5.85 95{\%} CI 1.24-27.46, P =.025) and a C-reactive protein greater than 5mg/L (HR 8.23 95{\%} CI 1.36-38.33, P =.020) were risk factors for ART-associated TB at multivariate analysis. In conclusion, with systematic TB screening (including culture and chest X-ray), the incidence of ART-associated TB is relatively low in settings with high HIV and TB prevalence.",
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