Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women

Michelle M. Estrella, Alison Gump Abraham, Yuezhou Jing, Rulan S. Parekh, Phyllis C. Tien, Dan Merenstein, Celeste Leigh Pearce, Kathryn Anastos, Mardge H. Cohen, Jack A. Dehovitz, Stephen J Gange

Research output: Contribution to journalArticle

Abstract

Natural history studies suggest increased risk for kidney function decline with HIV infection, but few studies have made comparisons with HIV-uninfected women. We examined whether HIV infection treated with highly active antiretroviral therapy (HAART) remains associated with faster kidney function decline in the Women's Interagency HIV Study. HIV-infected women initiating HAART with (n=105) or without (n=373) tenofovir (TDF) were matched to HIV-uninfected women on calendar and length of follow-up, age, systolic blood pressure, hepatitis C antibody serostatus, and diabetes history. Linear mixed models were used to evaluate differences in annual estimated glomerular filtration rate (eGFR). Person-visits were 4,741 and 11,512 for the TDF-treated and non-TDF-treated analyses, respectively. Mean baseline eGFRs were higher among women initiated on TDF-containing HAART and lower among those on TDF-sparing HAART compared to their respective HIV-uninfected matches (p0.05 for both). Adjusting for baseline eGFR, mean eGFRs at 1 and 3 years of follow-up among women initiated on TDF-containing HAART were lower than their uninfected matches (-4.98 and-4.26 ml/min/1.73 m2, respectively; p2, p=0.03). HAART-treated HIV-infected women had lower mean eGFRs at follow-up but experienced rates of annual eGFR decline similar to HIV-uninfected women. Tenofovir use in HIV-infected women with normal kidney function did not accelerate long-term kidney function decline relative to HIV-uninfected women.

Original languageEnglish (US)
Pages (from-to)755-760
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume29
Issue number5
DOIs
StatePublished - 2013

Fingerprint

HIV
Highly Active Antiretroviral Therapy
Kidney
Tenofovir
Glomerular Filtration Rate
HIV Infections
Blood Pressure
Hepatitis C Antibodies
Natural History
Linear Models
History

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women. / Estrella, Michelle M.; Abraham, Alison Gump; Jing, Yuezhou; Parekh, Rulan S.; Tien, Phyllis C.; Merenstein, Dan; Pearce, Celeste Leigh; Anastos, Kathryn; Cohen, Mardge H.; Dehovitz, Jack A.; Gange, Stephen J.

In: AIDS Research and Human Retroviruses, Vol. 29, No. 5, 2013, p. 755-760.

Research output: Contribution to journalArticle

Estrella, MM, Abraham, AG, Jing, Y, Parekh, RS, Tien, PC, Merenstein, D, Pearce, CL, Anastos, K, Cohen, MH, Dehovitz, JA & Gange, SJ 2013, 'Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women', AIDS Research and Human Retroviruses, vol. 29, no. 5, pp. 755-760. https://doi.org/10.1089/aid.2012.0248
Estrella, Michelle M. ; Abraham, Alison Gump ; Jing, Yuezhou ; Parekh, Rulan S. ; Tien, Phyllis C. ; Merenstein, Dan ; Pearce, Celeste Leigh ; Anastos, Kathryn ; Cohen, Mardge H. ; Dehovitz, Jack A. ; Gange, Stephen J. / Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women. In: AIDS Research and Human Retroviruses. 2013 ; Vol. 29, No. 5. pp. 755-760.
@article{1cd24055ca2c48d7833eb4c2e7e5cef3,
title = "Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women",
abstract = "Natural history studies suggest increased risk for kidney function decline with HIV infection, but few studies have made comparisons with HIV-uninfected women. We examined whether HIV infection treated with highly active antiretroviral therapy (HAART) remains associated with faster kidney function decline in the Women's Interagency HIV Study. HIV-infected women initiating HAART with (n=105) or without (n=373) tenofovir (TDF) were matched to HIV-uninfected women on calendar and length of follow-up, age, systolic blood pressure, hepatitis C antibody serostatus, and diabetes history. Linear mixed models were used to evaluate differences in annual estimated glomerular filtration rate (eGFR). Person-visits were 4,741 and 11,512 for the TDF-treated and non-TDF-treated analyses, respectively. Mean baseline eGFRs were higher among women initiated on TDF-containing HAART and lower among those on TDF-sparing HAART compared to their respective HIV-uninfected matches (p0.05 for both). Adjusting for baseline eGFR, mean eGFRs at 1 and 3 years of follow-up among women initiated on TDF-containing HAART were lower than their uninfected matches (-4.98 and-4.26 ml/min/1.73 m2, respectively; p2, p=0.03). HAART-treated HIV-infected women had lower mean eGFRs at follow-up but experienced rates of annual eGFR decline similar to HIV-uninfected women. Tenofovir use in HIV-infected women with normal kidney function did not accelerate long-term kidney function decline relative to HIV-uninfected women.",
author = "Estrella, {Michelle M.} and Abraham, {Alison Gump} and Yuezhou Jing and Parekh, {Rulan S.} and Tien, {Phyllis C.} and Dan Merenstein and Pearce, {Celeste Leigh} and Kathryn Anastos and Cohen, {Mardge H.} and Dehovitz, {Jack A.} and Gange, {Stephen J}",
year = "2013",
doi = "10.1089/aid.2012.0248",
language = "English (US)",
volume = "29",
pages = "755--760",
journal = "AIDS Research and Human Retroviruses",
issn = "0889-2229",
publisher = "Mary Ann Liebert Inc.",
number = "5",

}

TY - JOUR

T1 - Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women

AU - Estrella, Michelle M.

AU - Abraham, Alison Gump

AU - Jing, Yuezhou

AU - Parekh, Rulan S.

AU - Tien, Phyllis C.

AU - Merenstein, Dan

AU - Pearce, Celeste Leigh

AU - Anastos, Kathryn

AU - Cohen, Mardge H.

AU - Dehovitz, Jack A.

AU - Gange, Stephen J

PY - 2013

Y1 - 2013

N2 - Natural history studies suggest increased risk for kidney function decline with HIV infection, but few studies have made comparisons with HIV-uninfected women. We examined whether HIV infection treated with highly active antiretroviral therapy (HAART) remains associated with faster kidney function decline in the Women's Interagency HIV Study. HIV-infected women initiating HAART with (n=105) or without (n=373) tenofovir (TDF) were matched to HIV-uninfected women on calendar and length of follow-up, age, systolic blood pressure, hepatitis C antibody serostatus, and diabetes history. Linear mixed models were used to evaluate differences in annual estimated glomerular filtration rate (eGFR). Person-visits were 4,741 and 11,512 for the TDF-treated and non-TDF-treated analyses, respectively. Mean baseline eGFRs were higher among women initiated on TDF-containing HAART and lower among those on TDF-sparing HAART compared to their respective HIV-uninfected matches (p0.05 for both). Adjusting for baseline eGFR, mean eGFRs at 1 and 3 years of follow-up among women initiated on TDF-containing HAART were lower than their uninfected matches (-4.98 and-4.26 ml/min/1.73 m2, respectively; p2, p=0.03). HAART-treated HIV-infected women had lower mean eGFRs at follow-up but experienced rates of annual eGFR decline similar to HIV-uninfected women. Tenofovir use in HIV-infected women with normal kidney function did not accelerate long-term kidney function decline relative to HIV-uninfected women.

AB - Natural history studies suggest increased risk for kidney function decline with HIV infection, but few studies have made comparisons with HIV-uninfected women. We examined whether HIV infection treated with highly active antiretroviral therapy (HAART) remains associated with faster kidney function decline in the Women's Interagency HIV Study. HIV-infected women initiating HAART with (n=105) or without (n=373) tenofovir (TDF) were matched to HIV-uninfected women on calendar and length of follow-up, age, systolic blood pressure, hepatitis C antibody serostatus, and diabetes history. Linear mixed models were used to evaluate differences in annual estimated glomerular filtration rate (eGFR). Person-visits were 4,741 and 11,512 for the TDF-treated and non-TDF-treated analyses, respectively. Mean baseline eGFRs were higher among women initiated on TDF-containing HAART and lower among those on TDF-sparing HAART compared to their respective HIV-uninfected matches (p0.05 for both). Adjusting for baseline eGFR, mean eGFRs at 1 and 3 years of follow-up among women initiated on TDF-containing HAART were lower than their uninfected matches (-4.98 and-4.26 ml/min/1.73 m2, respectively; p2, p=0.03). HAART-treated HIV-infected women had lower mean eGFRs at follow-up but experienced rates of annual eGFR decline similar to HIV-uninfected women. Tenofovir use in HIV-infected women with normal kidney function did not accelerate long-term kidney function decline relative to HIV-uninfected women.

UR - http://www.scopus.com/inward/record.url?scp=84876948626&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876948626&partnerID=8YFLogxK

U2 - 10.1089/aid.2012.0248

DO - 10.1089/aid.2012.0248

M3 - Article

VL - 29

SP - 755

EP - 760

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

IS - 5

ER -