Antiretroviral therapy is associated with an atherogenic lipoprotein phenotype among HIV-1-infected men in the multicenter AIDS cohort study

Sharon A. Riddler, Xiuhong Li, James Otvos, Wendy Post, Frank Palella, Lawrence Kingsley, Barbara Visscher, Lisa P. Jacobson, A. R. Sharrett

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Alterations in serum lipids and an increased risk of myocardial infarction have been associated with HIV-1 infection and its treatment. METHODS: Lipoprotein subclasses were measured by nuclear magnetic resonance spectroscopy in frozen plasma samples from participants in the Multicenter AIDS Cohort Study. The effects of HIV-1 infection, antiretroviral therapy, and other factors on median particle concentrations were examined using quantile regression. RESULTS: Fasted samples were tested from 1082 men, including 609 HIV-seronegative and 473 HIV-1-infected men. Compared with HIV-seronegative men, HIV-1-infected men on antiretroviral therapy had an atherogenic phenotype with higher numbers of very low density lipoprotein and small low-density lipoprotein particles and lower numbers of high-density lipoprotein and large low-density lipoprotein particles. HIV-infected, antiretroviral-naive men had significantly lower high-density lipoprotein and small low-density lipoprotein particle concentrations compared with the HIV-seronegative men. Among men on antiretroviral therapy, the atherogenic phenotype was most pronounced in men with a good clinical status. CONCLUSION: Use of antiretroviral therapy in HIV-1-infected men was associated with an atherogenic lipoprotein phenotype.

Original languageEnglish (US)
Pages (from-to)281-288
Number of pages8
JournalJournal of acquired immune deficiency syndromes
Volume48
Issue number3
DOIs
StatePublished - Jul 1 2008

Keywords

  • Antiretroviral drugs
  • Dyslipidemia
  • HIV-1 infection
  • Lipoprotein subclasses
  • Nuclear magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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