Antiretroviral resistance during successful therapy of HIV type 1 infection

J. Martinez-Picado, M. P. DePasquale, N. Kartsonis, G. J. Hanna, J. Wong, D. Finzi, E. Rosenberg, H. F. Günthard, L. Sutton, A. Savara, C. J. Petropoulos, N. Hellmann, B. D. Walker, D. D. Richman, Robert F Siliciano, R. T. D'Aquila

Research output: Contribution to journalArticle

Abstract

HIV type 1 (HIV-1) drug resistance mutations were selected during antiretroviral therapy successfully suppressing plasma HIV-1 RNA to 50 copies/ml and virus env gene sequence changes. Each had received a suboptimal regimen before starting HAART. Antiretroviral-resistant HIV-1 can be selected from residual virus replication during HAART in the absence of sustained rebound of plasma HIV-1 RNA.

Original languageEnglish (US)
Pages (from-to)10948-10953
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number20
StatePublished - Sep 26 2000

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HIV Infections
HIV-1
Highly Active Antiretroviral Therapy
RNA
env Genes
Therapeutics
Virus Replication
Drug Resistance
Viruses
Mutation

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Martinez-Picado, J., DePasquale, M. P., Kartsonis, N., Hanna, G. J., Wong, J., Finzi, D., ... D'Aquila, R. T. (2000). Antiretroviral resistance during successful therapy of HIV type 1 infection. Proceedings of the National Academy of Sciences of the United States of America, 97(20), 10948-10953.

Antiretroviral resistance during successful therapy of HIV type 1 infection. / Martinez-Picado, J.; DePasquale, M. P.; Kartsonis, N.; Hanna, G. J.; Wong, J.; Finzi, D.; Rosenberg, E.; Günthard, H. F.; Sutton, L.; Savara, A.; Petropoulos, C. J.; Hellmann, N.; Walker, B. D.; Richman, D. D.; Siliciano, Robert F; D'Aquila, R. T.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 20, 26.09.2000, p. 10948-10953.

Research output: Contribution to journalArticle

Martinez-Picado, J, DePasquale, MP, Kartsonis, N, Hanna, GJ, Wong, J, Finzi, D, Rosenberg, E, Günthard, HF, Sutton, L, Savara, A, Petropoulos, CJ, Hellmann, N, Walker, BD, Richman, DD, Siliciano, RF & D'Aquila, RT 2000, 'Antiretroviral resistance during successful therapy of HIV type 1 infection', Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 20, pp. 10948-10953.
Martinez-Picado J, DePasquale MP, Kartsonis N, Hanna GJ, Wong J, Finzi D et al. Antiretroviral resistance during successful therapy of HIV type 1 infection. Proceedings of the National Academy of Sciences of the United States of America. 2000 Sep 26;97(20):10948-10953.
Martinez-Picado, J. ; DePasquale, M. P. ; Kartsonis, N. ; Hanna, G. J. ; Wong, J. ; Finzi, D. ; Rosenberg, E. ; Günthard, H. F. ; Sutton, L. ; Savara, A. ; Petropoulos, C. J. ; Hellmann, N. ; Walker, B. D. ; Richman, D. D. ; Siliciano, Robert F ; D'Aquila, R. T. / Antiretroviral resistance during successful therapy of HIV type 1 infection. In: Proceedings of the National Academy of Sciences of the United States of America. 2000 ; Vol. 97, No. 20. pp. 10948-10953.
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