Antiretroviral effects on host lipoproteins are associated with changes in hepatitis C virus (HCV) RNA levels in human immunodeficiency virus/HCV coinfected individuals

Susanna Naggie, Keyur Patel, Lan Yan Yang, Shein Chung Chow, Victoria Johnson, John R. Guyton, Andrew J. Muir, Mark Sulkowski, Charles Hicks

Research output: Contribution to journalArticle

Abstract

We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log10 HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients.

Original languageEnglish (US)
Article numberofv066
JournalOpen Forum Infectious Diseases
Volume2
Issue number2
DOIs
StatePublished - 2015

Fingerprint

Hepacivirus
Lipoproteins
HIV
RNA
Apolipoproteins
Metabolic Diseases
Dyslipidemias
Acquired Immunodeficiency Syndrome
Clinical Trials
Liver
Serum
Therapeutics

Keywords

  • Apolipoprotein CIII
  • Apolipoproteins
  • HCV
  • HCV RNA
  • HIV
  • Lipoproteins

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

Cite this

Antiretroviral effects on host lipoproteins are associated with changes in hepatitis C virus (HCV) RNA levels in human immunodeficiency virus/HCV coinfected individuals. / Naggie, Susanna; Patel, Keyur; Yang, Lan Yan; Chow, Shein Chung; Johnson, Victoria; Guyton, John R.; Muir, Andrew J.; Sulkowski, Mark; Hicks, Charles.

In: Open Forum Infectious Diseases, Vol. 2, No. 2, ofv066, 2015.

Research output: Contribution to journalArticle

Naggie, Susanna ; Patel, Keyur ; Yang, Lan Yan ; Chow, Shein Chung ; Johnson, Victoria ; Guyton, John R. ; Muir, Andrew J. ; Sulkowski, Mark ; Hicks, Charles. / Antiretroviral effects on host lipoproteins are associated with changes in hepatitis C virus (HCV) RNA levels in human immunodeficiency virus/HCV coinfected individuals. In: Open Forum Infectious Diseases. 2015 ; Vol. 2, No. 2.
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