Antiretroviral drug use in a cohort of HIV-uninfected women in the United States: HIV Prevention Trials Network 064

Iris Chen; William Clarke; San San Ou; Mark A. Marzinke; Autumn Breaud; Lynda M. Emel; Jing Wang; James P. Hughes; Paul Richardson; Danielle F. Haley; Jonathan Lucas; Anne Rompalo; Jessica E. Justman; Sally L. Hodder; Susan H. Eshleman

doi:10.1371/journal.pone.0140074

Antiretroviral drug use in a cohort of HIV-uninfected women in the United States: HIV Prevention Trials Network 064

Iris Chen, William Clarke, San San Ou, Mark A. Marzinke, Autumn Breaud, Lynda M. Emel, Jing Wang, James P. Hughes, Paul Richardson, Danielle F. Haley, Jonathan Lucas, Anne Rompalo, Jessica E. Justman, Sally L. Hodder, Susan H. Eshleman

School of Medicine

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Abstract

Antiretroviral (ARV) drug use was analyzed in HIV-uninfected women in an observational cohort study conducted in 10 urban and periurban communities in the United States with high rates of poverty and HIV infection. Plasma samples collected in 2009-2010 were tested for the presence of 16 ARV drugs. ARV drugs were detected in samples from 39 (2%) of 1,806 participants: 27/181 (15%) in Baltimore, MD and 12/179 (7%) in Bronx, NY. The ARV drugs detected included different combinations of non-nucleoside reverse transcriptase inhibitors and protease inhibitors (1-4 drugs/sample). These data were analyzed in the context of self-reported data on ARV drug use. None of the 39 women who had ARV drugs detected reported ARV drug use at any study visit. Further research is needed to evaluate ARV drug use by HIV-uninfected individuals.

Original language	English (US)
Article number	e0140074
Journal	PloS one
Volume	10
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0140074
State	Published - Oct 7 2015

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Chen, I., Clarke, W., Ou, S. S., Marzinke, M. A., Breaud, A., Emel, L. M., Wang, J., Hughes, J. P., Richardson, P., Haley, D. F., Lucas, J., Rompalo, A., Justman, J. E., Hodder, S. L., & Eshleman, S. H. (2015). Antiretroviral drug use in a cohort of HIV-uninfected women in the United States: HIV Prevention Trials Network 064. PloS one, 10(10), Article e0140074. https://doi.org/10.1371/journal.pone.0140074

Chen, I, Clarke, W, Ou, SS, Marzinke, MA, Breaud, A, Emel, LM, Wang, J, Hughes, JP, Richardson, P, Haley, DF, Lucas, J, Rompalo, A, Justman, JE, Hodder, SL & Eshleman, SH 2015, 'Antiretroviral drug use in a cohort of HIV-uninfected women in the United States: HIV Prevention Trials Network 064', PloS one, vol. 10, no. 10, e0140074. https://doi.org/10.1371/journal.pone.0140074

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abstract = "Antiretroviral (ARV) drug use was analyzed in HIV-uninfected women in an observational cohort study conducted in 10 urban and periurban communities in the United States with high rates of poverty and HIV infection. Plasma samples collected in 2009-2010 were tested for the presence of 16 ARV drugs. ARV drugs were detected in samples from 39 (2%) of 1,806 participants: 27/181 (15%) in Baltimore, MD and 12/179 (7%) in Bronx, NY. The ARV drugs detected included different combinations of non-nucleoside reverse transcriptase inhibitors and protease inhibitors (1-4 drugs/sample). These data were analyzed in the context of self-reported data on ARV drug use. None of the 39 women who had ARV drugs detected reported ARV drug use at any study visit. Further research is needed to evaluate ARV drug use by HIV-uninfected individuals.",

author = "Iris Chen and William Clarke and Ou, {San San} and Marzinke, {Mark A.} and Autumn Breaud and Emel, {Lynda M.} and Jing Wang and Hughes, {James P.} and Paul Richardson and Haley, {Danielle F.} and Jonathan Lucas and Anne Rompalo and Justman, {Jessica E.} and Hodder, {Sally L.} and Eshleman, {Susan H.}",

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AU - Hughes, James P.

AU - Richardson, Paul

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AU - Hodder, Sally L.

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Antiretroviral drug use in a cohort of HIV-uninfected women in the United States: HIV Prevention Trials Network 064

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