Antipyrine kinetics in patients with primary biliary cirrhosis

L. L. Von Moltke, D. R. Abernethy, M. M. Kaplan, D. J. Greenblatt

Research output: Contribution to journalArticle

Abstract

Fourteen antimitochrodrial antibody-positive patients (13 women, 1 man) with biopsy-proven primary biliary cirrhosis, aged 40 to 71 years (mean, 57 years) weighing 43 to 102 kg (mean, 63 kg), along with 14 age- and sex-matched healthy controls, received a single 1.0- to 1.2-g dose of intravenous antipyrine. Plasma antipyrine levels were determined during a 12- to 24-hour period. Patients' mean serum chemistry values were: albumin, 3.9 g/dL (range, 3.1-4.4) and total bilirubin, 1.9 mg/dL (range, 0.3-10.9). Seven of the fourteen patients had cirrhosis. Mean kinetic variables for antipyrine in controls and primary biliary cirrhosis patients were: Vd, .54 versus .49 L/kg; half-life, 12.0 versus 15.1 hours (P < .07); clearance, .55 versus .41 mL/min/kg (P < .04). Within the primary biliary cirrhosis group, there was no correlation between total bilirubin and clearance (r = .09), nor did clearance vary significantly among histologic categories. Clearance of antipyrine in primary biliary cirrhosis patients is reduced by an average of 25%, but the clinical prognosticators of serum bilirubin levels and histologic grade do not correlate with or predict the degree of clearance impairment.

Original languageEnglish (US)
Pages (from-to)75-78
Number of pages4
JournalJournal of clinical pharmacology
Volume33
Issue number1
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Von Moltke, L. L., Abernethy, D. R., Kaplan, M. M., & Greenblatt, D. J. (1993). Antipyrine kinetics in patients with primary biliary cirrhosis. Journal of clinical pharmacology, 33(1), 75-78. https://doi.org/10.1002/j.1552-4604.1993.tb03907.x