Antipsychotic treatment patterns and hospitalizations among adults with schizophrenia

Susan dosReis, Elizabeth Johnson, Donald Steinwachs, Charles Rohde, Elizabeth A. Skinner, Maureen Fahey, Anthony F. Lehman

Research output: Contribution to journalArticlepeer-review

Abstract

Objective(s): To characterize the longitudinal patterns of antipsychotic treatment and to investigate the relationship between antipsychotic treatment patterns and acute hospitalizations among adults with schizophrenia. We hypothesized that continuous antipsychotic treatment would be associated with fewer hospitalizations and shorter lengths of stay. Method: Seven years of retrospective Maryland Medicaid administrative data were used to examine inpatient medical encounters and outpatient psychotropic treatment in community-based settings from 1993 through 2000. The sample consisted of 1727 adults continuously enrolled in the Maryland Medicaid program from July 1992 through June 1994, and diagnosed with schizophrenia. The main outcome measures were a) any schizophrenia hospitalization; b) number of schizophrenia hospitalizations; and c) inpatient days associated with a primary diagnosis of schizophrenia. Results: The average duration of antipsychotic use was six months in any single year and four and one-half years across the entire study period. Compared to individuals with a more continuous pattern of antipsychotic treatment, individuals with moderate or light use had odds of hospitalization for schizophrenia that were 52 or 72% greater (95%CI: 30-75% greater, 49-100% greater respectively). Light users of antipsychotics have an average length of stay per hospitalization that is approximately 20% longer than the average for continuous users (95%CI: 2-39% longer). Conclusions: Findings emphasize the benefit of continuous antipsychotic treatment for individuals with schizophrenia.

Original languageEnglish (US)
Pages (from-to)304-311
Number of pages8
JournalSchizophrenia Research
Volume101
Issue number1-3
DOIs
StatePublished - Apr 2008

Keywords

  • Antipsychotic use
  • Longitudinal analysis
  • Medicaid
  • Schizophrenia
  • Severe mental illness

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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