Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009)

Yu Tao Xiang, Julie Kreyenbuhl, Faith B. Dickerson, Gabor S. Ungvari, Chuan Yue Wang, Tian Mei Si, Edwin H M Lee, Helen F K Chiu, Kelly Y C Lai, Yan Ling He, Shu Yu Yang, Mian Yoon Chong, Chay Hoon Tan, Ee Heok Kua, Senta Fujii, Kang Sim, Michael K H Yong, Jitendra K. Trivedi, Eun Kee Chung, Pichet UdomratnKok Yoon Chee, Norman Sartorius, Naotaka Shinfuku

Research output: Contribution to journalArticlepeer-review


Objective: This study surveyed the prescribing patterns of antipsychotic medications in Asian older schizophrenia patients with extrapyramidal side effects (EPS) during the period between 2001 and 2009. Method: Information on 848 hospitalized patients with schizophrenia aged 60 or older was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (2001 - 2009). Data from those patients with reported EPS from 8 Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, Taiwan, India and Malaysia were analyzed. The cross-sectional data of socio-demographic and clinical characteristics and antipsychotic prescriptions were collected using a standardized protocol and data collection procedure. Results: Of the 309/848 (36%) patients suffering from EPS, 210 patients (210/309; 68.0%) received at least one type of first generation antipsychotic (FGA), and 99 (99/309; 32.0%) received second generation antipsychotics (SGAs) only. Of SGAs prescribed in patients with EPS, risperidone was the most commonly used (100/309; 32.4%) followed by olanzapine (33/309; 10.7%) and quetiapine (25/309; 8.1%). Conclusions: FGAs were frequently used in Asian older schizophrenia patients with EPS. Considering the potential adverse effects of FGAs on existing EPS, the reasons for the frequent use of FGAs need to be urgently identified.

Original languageEnglish (US)
Pages (from-to)500-504
Number of pages5
JournalInternational Journal of Clinical Pharmacology and Therapeutics
Issue number7
StatePublished - Jul 2012


  • Extrapyramidal side effects
  • Older patients
  • Prescription patterns
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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