Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase

Sangwon F. Kim, Alex S. Huang, Adele M. Snowman, Cory Teuscher, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review


The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We report that orexigenic AAPDs potently and selectively activate hypothalamic AMP-kinase, an action abolished in mice with deletion of histamine H1 receptors. These findings may afford a means of developing more effective therapeutic agents and provide insight into the hypothalamic regulation of food intake.

Original languageEnglish (US)
Pages (from-to)3456-3459
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number9
StatePublished - Feb 27 2007


  • Atypical antipsychotic drugs
  • Hypothalamus
  • Obesity

ASJC Scopus subject areas

  • General

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