TY - JOUR
T1 - Antipsychotic dose and diminished neural modulation
T2 - A multi-site fMRI study
AU - Abbott, C.
AU - Juárez, M.
AU - White, T.
AU - Gollub, R. L.
AU - Pearlson, G. D.
AU - Bustillo, J.
AU - Lauriello, J.
AU - Ho, B.
AU - Bockholt, H. J.
AU - Clark, V. P.
AU - Magnotta, V.
AU - Calhoun, V. D.
N1 - Funding Information:
The Department of Energy DE-FG02-99ER62764 , NIH NCRR P41RR14075 , 5MO1-RR001066 , and U24 RR021992 funded data collection. National Institutes of Health grant R01 EB000840 and K08 MH068540 also funded this study. The authors would like to thank the Mind Research Network staff for their efforts during the data collection processes and Guilherme Machado for help with data organization and analysis.
PY - 2011/3/30
Y1 - 2011/3/30
N2 - Background: The effect of antipsychotics on the blood oxygen level dependent signal in schizophrenia is poorly understood. The purpose of the present investigation is to examine the effect of antipsychotic medication on independent neural networks during a motor task in a large, multi-site functional magnetic resonance imaging investigation. Methods: Seventy-nine medicated patients with schizophrenia and 114 comparison subjects from the Mind Clinical Imaging Consortium database completed a paced, auditory motor task during functional magnetic resonance imaging (fMRI). Independent component analysis identified temporally cohesive but spatially distributed neural networks. The independent component analysis time course was regressed with a model time course of the experimental design. The resulting beta weights were evaluated for group comparisons and correlations with chlorpromazine equivalents. Results: Group differences between patients and comparison subjects were evident in the cortical and subcortical motor networks, default mode networks, and attentional networks. The chlorpromazine equivalents correlated with the unimotor/bitemporal (rho=-0.32, P=0.0039), motor/caudate (rho=-0.22, P=0.046), posterior default mode (rho=0.26, P=0.020), and anterior default mode networks (rho=0.24, P=0.03). Patients on typical antipsychotics also had less positive modulation of the motor/caudate network relative to patients on atypical antipsychotics (t 77=2.01, P=0.048). Conclusion: The results suggest that antipsychotic dose diminishes neural activation in motor (cortical and subcortical) and default mode networks in patients with schizophrenia. The higher potency, typical antipsychotics also diminish positive modulation in subcortical motor networks. Antipsychotics may be a potential confound limiting interpretation of fMRI studies on the disease process in medicated patients with schizophrenia.
AB - Background: The effect of antipsychotics on the blood oxygen level dependent signal in schizophrenia is poorly understood. The purpose of the present investigation is to examine the effect of antipsychotic medication on independent neural networks during a motor task in a large, multi-site functional magnetic resonance imaging investigation. Methods: Seventy-nine medicated patients with schizophrenia and 114 comparison subjects from the Mind Clinical Imaging Consortium database completed a paced, auditory motor task during functional magnetic resonance imaging (fMRI). Independent component analysis identified temporally cohesive but spatially distributed neural networks. The independent component analysis time course was regressed with a model time course of the experimental design. The resulting beta weights were evaluated for group comparisons and correlations with chlorpromazine equivalents. Results: Group differences between patients and comparison subjects were evident in the cortical and subcortical motor networks, default mode networks, and attentional networks. The chlorpromazine equivalents correlated with the unimotor/bitemporal (rho=-0.32, P=0.0039), motor/caudate (rho=-0.22, P=0.046), posterior default mode (rho=0.26, P=0.020), and anterior default mode networks (rho=0.24, P=0.03). Patients on typical antipsychotics also had less positive modulation of the motor/caudate network relative to patients on atypical antipsychotics (t 77=2.01, P=0.048). Conclusion: The results suggest that antipsychotic dose diminishes neural activation in motor (cortical and subcortical) and default mode networks in patients with schizophrenia. The higher potency, typical antipsychotics also diminish positive modulation in subcortical motor networks. Antipsychotics may be a potential confound limiting interpretation of fMRI studies on the disease process in medicated patients with schizophrenia.
KW - Antipsychotic
KW - Default mode network
KW - FMRI
KW - Independent component analysis
KW - Motor cortex
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U2 - 10.1016/j.pnpbp.2010.12.001
DO - 10.1016/j.pnpbp.2010.12.001
M3 - Article
C2 - 21185903
AN - SCOPUS:79952901624
VL - 35
SP - 473
EP - 482
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 2
ER -