Antiplatelet effects of aspirin with phytosterols

Comparison with non-enteric coated aspirin alone

Mark J. Antonino, Rosa Coppolecchia, Elisabeth Mahla, Kevin P. Bliden, Udaya S. Tantry, Paul A. Gurbel

Research output: Contribution to journalArticle

Abstract

The novel combination of aspirin and phytosterols may be a potential strategy to treat patients with cardiovascular disease. We sought to determine if the antiplatelet effects of a combination caplet of 81 mg aspirin with 400 mg phytosterols differed from the antiplatelet effects of non-enteric coated aspirin. The first five days of aspirin therapy alone (T1) produced marked reductions in collagen-induced, ADP-induced, and archidonic acid- induced platelet aggregation, and in serum and urine TxB2 compared to baseline. Five days after randomization to aspirin alone versus aspirin + phytosterols (T2), there were no differences in any measurement of platelet function within each group compared to T1 or between groups. The present study suggests that the antiplatelet effect of non-enteric coated 81 mg twice-daily aspirin therapy alone is not affected by the addition of phytosterols in a combination product.

Original languageEnglish (US)
Pages (from-to)384-385
Number of pages2
JournalThrombosis Research
Volume126
Issue number5
DOIs
StatePublished - Nov 2010

Fingerprint

Phytosterols
Aspirin
Random Allocation
Platelet Aggregation
Adenosine Diphosphate
Cardiovascular Diseases
Collagen
Blood Platelets
Urine
Acids
Therapeutics
Serum

Keywords

  • Aggregation
  • Aspirin
  • Phytosterols
  • Platelets
  • Thromboxane

ASJC Scopus subject areas

  • Hematology

Cite this

Antonino, M. J., Coppolecchia, R., Mahla, E., Bliden, K. P., Tantry, U. S., & Gurbel, P. A. (2010). Antiplatelet effects of aspirin with phytosterols: Comparison with non-enteric coated aspirin alone. Thrombosis Research, 126(5), 384-385. https://doi.org/10.1016/j.thromres.2009.05.003

Antiplatelet effects of aspirin with phytosterols : Comparison with non-enteric coated aspirin alone. / Antonino, Mark J.; Coppolecchia, Rosa; Mahla, Elisabeth; Bliden, Kevin P.; Tantry, Udaya S.; Gurbel, Paul A.

In: Thrombosis Research, Vol. 126, No. 5, 11.2010, p. 384-385.

Research output: Contribution to journalArticle

Antonino, MJ, Coppolecchia, R, Mahla, E, Bliden, KP, Tantry, US & Gurbel, PA 2010, 'Antiplatelet effects of aspirin with phytosterols: Comparison with non-enteric coated aspirin alone', Thrombosis Research, vol. 126, no. 5, pp. 384-385. https://doi.org/10.1016/j.thromres.2009.05.003
Antonino, Mark J. ; Coppolecchia, Rosa ; Mahla, Elisabeth ; Bliden, Kevin P. ; Tantry, Udaya S. ; Gurbel, Paul A. / Antiplatelet effects of aspirin with phytosterols : Comparison with non-enteric coated aspirin alone. In: Thrombosis Research. 2010 ; Vol. 126, No. 5. pp. 384-385.
@article{f1af75e223c441a8acbe2d44e000d28d,
title = "Antiplatelet effects of aspirin with phytosterols: Comparison with non-enteric coated aspirin alone",
abstract = "The novel combination of aspirin and phytosterols may be a potential strategy to treat patients with cardiovascular disease. We sought to determine if the antiplatelet effects of a combination caplet of 81 mg aspirin with 400 mg phytosterols differed from the antiplatelet effects of non-enteric coated aspirin. The first five days of aspirin therapy alone (T1) produced marked reductions in collagen-induced, ADP-induced, and archidonic acid- induced platelet aggregation, and in serum and urine TxB2 compared to baseline. Five days after randomization to aspirin alone versus aspirin + phytosterols (T2), there were no differences in any measurement of platelet function within each group compared to T1 or between groups. The present study suggests that the antiplatelet effect of non-enteric coated 81 mg twice-daily aspirin therapy alone is not affected by the addition of phytosterols in a combination product.",
keywords = "Aggregation, Aspirin, Phytosterols, Platelets, Thromboxane",
author = "Antonino, {Mark J.} and Rosa Coppolecchia and Elisabeth Mahla and Bliden, {Kevin P.} and Tantry, {Udaya S.} and Gurbel, {Paul A.}",
year = "2010",
month = "11",
doi = "10.1016/j.thromres.2009.05.003",
language = "English (US)",
volume = "126",
pages = "384--385",
journal = "Thrombosis Research",
issn = "0049-3848",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Antiplatelet effects of aspirin with phytosterols

T2 - Comparison with non-enteric coated aspirin alone

AU - Antonino, Mark J.

AU - Coppolecchia, Rosa

AU - Mahla, Elisabeth

AU - Bliden, Kevin P.

AU - Tantry, Udaya S.

AU - Gurbel, Paul A.

PY - 2010/11

Y1 - 2010/11

N2 - The novel combination of aspirin and phytosterols may be a potential strategy to treat patients with cardiovascular disease. We sought to determine if the antiplatelet effects of a combination caplet of 81 mg aspirin with 400 mg phytosterols differed from the antiplatelet effects of non-enteric coated aspirin. The first five days of aspirin therapy alone (T1) produced marked reductions in collagen-induced, ADP-induced, and archidonic acid- induced platelet aggregation, and in serum and urine TxB2 compared to baseline. Five days after randomization to aspirin alone versus aspirin + phytosterols (T2), there were no differences in any measurement of platelet function within each group compared to T1 or between groups. The present study suggests that the antiplatelet effect of non-enteric coated 81 mg twice-daily aspirin therapy alone is not affected by the addition of phytosterols in a combination product.

AB - The novel combination of aspirin and phytosterols may be a potential strategy to treat patients with cardiovascular disease. We sought to determine if the antiplatelet effects of a combination caplet of 81 mg aspirin with 400 mg phytosterols differed from the antiplatelet effects of non-enteric coated aspirin. The first five days of aspirin therapy alone (T1) produced marked reductions in collagen-induced, ADP-induced, and archidonic acid- induced platelet aggregation, and in serum and urine TxB2 compared to baseline. Five days after randomization to aspirin alone versus aspirin + phytosterols (T2), there were no differences in any measurement of platelet function within each group compared to T1 or between groups. The present study suggests that the antiplatelet effect of non-enteric coated 81 mg twice-daily aspirin therapy alone is not affected by the addition of phytosterols in a combination product.

KW - Aggregation

KW - Aspirin

KW - Phytosterols

KW - Platelets

KW - Thromboxane

UR - http://www.scopus.com/inward/record.url?scp=78149284695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78149284695&partnerID=8YFLogxK

U2 - 10.1016/j.thromres.2009.05.003

DO - 10.1016/j.thromres.2009.05.003

M3 - Article

VL - 126

SP - 384

EP - 385

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - 5

ER -