Antioxidant status and acute malaria in children in Kampala, Uganda

A. Metzger, G. Mukasa, A. H. Shankar, G. Ndeezi, G. Melikian, Richard David Semba

Research output: Contribution to journalArticle

Abstract

Although antioxidant status has been implicated in the pathogenesis of malaria, these factors need further characterization. A longitudinal study was conducted involving 273 children 1-10 years of age with acute, uncomplicated malaria in Kampala, Uganda. Plasma vitamin A, carotenoids, and vitamin E were measured at enrollment and on day 7. Malaria parasitemia was measured at enrollment, on day 3, and on day 7. Malaria parasitemia had completely cleared in 57.1% and 85.3% of children by day 3 and day 7, respectively. Plasma vitamin A, α-carotene, β-carotene, lycopene, lutein/zeaxanthin, and vitamin E were depressed at enrollment and increased by day 7. Multivariate analyses showed that higher plasma lycopene concentrations at enrollment were associated with clearance of parasitemia between enrollment and day 3 (odds ratio = 1.46, 95% confidence interval = 1.07-2.06, per 0.10 μmol/L of lycopene). This study suggests that children with acute malaria have depressed plasma concentrations of antioxidants, and that higher plasma lycopene is associated with more rapid clearance of malaria parasitemia.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume65
Issue number2
StatePublished - 2001
Externally publishedYes

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Uganda
Parasitemia
Antioxidants
Malaria
Carotenoids
Lutein
Vitamin A
Vitamin E
Longitudinal Studies
Multivariate Analysis
Odds Ratio
Acute malaria
Confidence Intervals
lycopene

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Metzger, A., Mukasa, G., Shankar, A. H., Ndeezi, G., Melikian, G., & Semba, R. D. (2001). Antioxidant status and acute malaria in children in Kampala, Uganda. American Journal of Tropical Medicine and Hygiene, 65(2), 115-119.

Antioxidant status and acute malaria in children in Kampala, Uganda. / Metzger, A.; Mukasa, G.; Shankar, A. H.; Ndeezi, G.; Melikian, G.; Semba, Richard David.

In: American Journal of Tropical Medicine and Hygiene, Vol. 65, No. 2, 2001, p. 115-119.

Research output: Contribution to journalArticle

Metzger, A, Mukasa, G, Shankar, AH, Ndeezi, G, Melikian, G & Semba, RD 2001, 'Antioxidant status and acute malaria in children in Kampala, Uganda', American Journal of Tropical Medicine and Hygiene, vol. 65, no. 2, pp. 115-119.
Metzger, A. ; Mukasa, G. ; Shankar, A. H. ; Ndeezi, G. ; Melikian, G. ; Semba, Richard David. / Antioxidant status and acute malaria in children in Kampala, Uganda. In: American Journal of Tropical Medicine and Hygiene. 2001 ; Vol. 65, No. 2. pp. 115-119.
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