The function of nitric oxide (•NO) in pathophysiology remains confounding as both protective and cytotoxic effects of •NO have been demonstrated in many disease processes. Nitric oxide chemistry culminating in the generation of oxidative as well as nitrosative intermediates have generally been proposed as mediators of pathophysiology and have overshadowed the antioxidant capabilities of •NO. However, the counteracting role of •NO in providing a balance under conditions of oxidative and nitrosative stress has been underappreciated. The purpose of this review is the discussion of the role of •NO as an antioxidant and interceptor of more potent reactive intermediates in normal physiology and disease.
|Original language||English (US)|
|Number of pages||8|
|Journal||Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents|
|State||Published - Sep 1 2004|
ASJC Scopus subject areas
- Immunology and Allergy