Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment

Ixane Velázquez, Marinés Plaud, Valerie Wojna, Richard Skolasky, Juliana Pérez Laspiur, Loyda M. Meléndez

Research output: Contribution to journalArticlepeer-review

Abstract

HIV-associated cognitive neurological disorders (HAND) prevail in the antiretroviral therapy era. Proteomics analysis of CSF revealed expression of Cu/Zn superoxide dismutase (Cu/Zn SOD) in Hispanic women with cognitive impairment (CI). We tested the hypothesis that there is reduced capacity of antioxidant enzymes in CI by measures of expression and activity of Cu/Zn SOD, catalase, and Se-glutathione peroxidase in HAND. Our results showed that the function of these antioxidants was decreased in the CSF and monocytes of women with CI. These findings have important implications regarding their possible contribution to oxidative stress and in the diagnosis and therapy for HAND.

Original languageEnglish (US)
Pages (from-to)106-111
Number of pages6
JournalJournal of Neuroimmunology
Volume206
Issue number1-2
DOIs
StatePublished - Jan 3 2009

Keywords

  • Antioxidant enzymes
  • Cu/Zn SOD
  • HAART
  • HIV-associated cognitive impairment
  • Women

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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