Antioxidant enzyme activity and coronary heart disease: Meta-analyses of observational studies

María Isabel Covas, Gemma Flores-Mateo, Paloma Carrillo-Santisteve, Roberto Elosua, Eliseo Guallar, Jaume Marrugat, Joachim Bleys

Research output: Contribution to journalArticlepeer-review

Abstract

Controversial data exist concerning the relation between the activities of scavenger antioxidant enzymes and coronary heart disease (CHD) risk. The authors report updated meta-analyses of studies assessing the activities of 3 antioxidant enzymes - glutathione peroxidase, superoxide dismutase, and catalase - and CHD risk. Computer-based and manual searches of the relevant literature from January 1966 to January 2008 were performed. Studies assessing glutathione peroxidase, superoxide dismutase, and catalase activities in cells or biologic fluids and clinical CHD outcomes were selected. Pooled odds ratios for CHD were calculated by using an inverse-variance-weighted random-effects model. Forty-two case-control studies and 3 prospective studies were included. The pooled odds ratios for CHD associated with a 1-standard-deviation increase in glutathione peroxidase, superoxide dismutase, and catalase activity levels were 0.51 (95% confidence interval: 0.35, 0.75), 0.48 (95% confidence interval: 0.32, 0.72), and 0.32 (95% confidence interval: 0.16, 0.61), respectively, with substantial between-study heterogeneity (I 2>90% for the 3 enzymes). These findings were remarkably robust in the sensitivity analysis. The authors' meta-analyses support an inverse association between circulating levels of superoxide dismutase, glutathione peroxidase, and catalase activities with CHD and emphasize the need for additional high-quality prospective studies.

Original languageEnglish (US)
Pages (from-to)135-147
Number of pages13
JournalAmerican journal of epidemiology
Volume170
Issue number2
DOIs
StatePublished - Jul 2009
Externally publishedYes

Keywords

  • Cardiovascular diseases
  • Catalase
  • Coronary disease
  • Glutathione peroxidase
  • Meta-analysis
  • Superoxide dismutase

ASJC Scopus subject areas

  • Epidemiology

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