Antioxidant effects of 1,5-anhydro-d-fructose, a new natural sugar, in vitro

Kazuyo Yamaji; Krishna Pada Sarker; Ikuro Maruyama; Susumu Hizukuri

doi:10.1055/s-2002-20050

Antioxidant effects of 1,5-anhydro-d-fructose, a new natural sugar, in vitro

Kazuyo Yamaji, Krishna Pada Sarker, Ikuro Maruyama, Susumu Hizukuri

School of Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.

Original language	English (US)
Pages (from-to)	16-19
Number of pages	4
Journal	Planta Medica
Volume	68
Issue number	1
DOIs	https://doi.org/10.1055/s-2002-20050
State	Published - Feb 11 2002

Keywords

1,5-Anhydro-D-fructose
Antioxidant
Low-density lipoprotein peroxidation
Reactive oxygen species

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Antioxidant effects of 1,5-anhydro-d-fructose, a new natural sugar, in vitro",

abstract = "The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.",

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AU - Maruyama, Ikuro

AU - Hizukuri, Susumu

PY - 2002/2/11

Y1 - 2002/2/11

N2 - The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.

AB - The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.

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KW - Antioxidant

KW - Low-density lipoprotein peroxidation

KW - Reactive oxygen species

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Antioxidant effects of 1,5-anhydro-d-fructose, a new natural sugar, in vitro

Abstract

Keywords

ASJC Scopus subject areas

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