Antioxidant effects of 1,5-anhydro-d-fructose, a new natural sugar, in vitro

Kazuyo Kegan, Krishna Pada Sarker, Ikuro Maruyama, Susumu Hizukuri

Research output: Contribution to journalArticle

Abstract

The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
JournalPlanta Medica
Volume68
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

low density lipoprotein
Fructose
LDL Lipoproteins
Sugars
fructose
Antioxidants
sugars
antioxidants
Tetradecanoylphorbol Acetate
dosage
atherosclerosis
Superoxides
superoxide anion
biphenyl
Hydrogen Peroxide
Lipid Peroxidation
Coronary Disease
hydrogen peroxide
Copper
reactive oxygen species

Keywords

  • 1,5-Anhydro-D-fructose
  • Antioxidant
  • Low-density lipoprotein peroxidation
  • Reactive oxygen species

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antioxidant effects of 1,5-anhydro-d-fructose, a new natural sugar, in vitro. / Kegan, Kazuyo; Pada Sarker, Krishna; Maruyama, Ikuro; Hizukuri, Susumu.

In: Planta Medica, Vol. 68, No. 1, 2002, p. 16-19.

Research output: Contribution to journalArticle

Kegan, K, Pada Sarker, K, Maruyama, I & Hizukuri, S 2002, 'Antioxidant effects of 1,5-anhydro-d-fructose, a new natural sugar, in vitro', Planta Medica, vol. 68, no. 1, pp. 16-19. https://doi.org/10.1055/s-2002-20050
Kegan, Kazuyo ; Pada Sarker, Krishna ; Maruyama, Ikuro ; Hizukuri, Susumu. / Antioxidant effects of 1,5-anhydro-d-fructose, a new natural sugar, in vitro. In: Planta Medica. 2002 ; Vol. 68, No. 1. pp. 16-19.
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