TY - JOUR
T1 - Antioxidant, antiinflammatory and antiinvasive activities of biopolyphenolics
AU - Malhotra, Shashwat
AU - Shakya, Gaurav
AU - Kumar, Ajit
AU - Vanhoecke, Barbara W.
AU - Cholli, Ashok L.
AU - Raj, Hanumantharao G.
AU - Saso, Luciano
AU - Ghosh, Balaram
AU - Bracke, Marc E.
AU - Prasad, Ashok K.
AU - Biswal, Shyam
AU - Parmar, Virinder S.
PY - 2008/6/15
Y1 - 2008/6/15
N2 - A large number of polyphenolic and heterocyclic compounds, i.e. 4-methylcoumarins, 4-methylthionocoumarins, xanthones, pyrazoles, pyrazolylacrylonitriles, flavones and isoflavones have been tested for their antioxidant activity towards NADPH-catalysed liver-microsomal lipid peroxidation with a view to establish their structure-activity relationship. Inhibition of microsomal lipid peroxidation by 7,8-dihydroxy-4-methylcoumarin (DHMC, 2) and 7,8-diacetoxy-4-methylcoumarin (DAMC, 3) was intriguing. We also found that dihydroxy and diacetoxy derivatives of 4-methylthionocoumarin were more potent in comparison to the corresponding coumarin derivatives in inhibiting TNF-α induced expression of ICAM-1. The effect of nine different xanthones has been examined on the modulation of cytokine-induced expression of ICAM-1 in human endothelial cells. 1,4-Dihydroxyxanthone (10) showed enhanced antioxidant activity as well as the inhibition of the expression of cell adhesion molecules, such as ICAM-1, VCAM-1 and E-selectin on endothelial cells in a concentration and time dependent manner. Antioxidant activity of different pyrazoles and pyrazolylacrylonitriles and antiinvasive activity of flavones and isoflavones against solid tumors have also been studied.
AB - A large number of polyphenolic and heterocyclic compounds, i.e. 4-methylcoumarins, 4-methylthionocoumarins, xanthones, pyrazoles, pyrazolylacrylonitriles, flavones and isoflavones have been tested for their antioxidant activity towards NADPH-catalysed liver-microsomal lipid peroxidation with a view to establish their structure-activity relationship. Inhibition of microsomal lipid peroxidation by 7,8-dihydroxy-4-methylcoumarin (DHMC, 2) and 7,8-diacetoxy-4-methylcoumarin (DAMC, 3) was intriguing. We also found that dihydroxy and diacetoxy derivatives of 4-methylthionocoumarin were more potent in comparison to the corresponding coumarin derivatives in inhibiting TNF-α induced expression of ICAM-1. The effect of nine different xanthones has been examined on the modulation of cytokine-induced expression of ICAM-1 in human endothelial cells. 1,4-Dihydroxyxanthone (10) showed enhanced antioxidant activity as well as the inhibition of the expression of cell adhesion molecules, such as ICAM-1, VCAM-1 and E-selectin on endothelial cells in a concentration and time dependent manner. Antioxidant activity of different pyrazoles and pyrazolylacrylonitriles and antiinvasive activity of flavones and isoflavones against solid tumors have also been studied.
KW - Coumarins
KW - Flavones and isoflavones
KW - Reactive oxygen species
KW - Xanthones
UR - http://www.scopus.com/inward/record.url?scp=45849119832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45849119832&partnerID=8YFLogxK
U2 - 10.3998/ark.5550190.0009.612
DO - 10.3998/ark.5550190.0009.612
M3 - Review article
AN - SCOPUS:45849119832
VL - 2008
SP - 119
EP - 139
JO - Arkivoc
JF - Arkivoc
SN - 1551-7004
IS - 6
ER -