Antinuclear antibodies in sera of patients with recurrent pregnancy wastage

Ling Xu, Victoria Chang, Ana Murphy, John A. Rock, Marian Damewood, William Schlaff, Howard A Zacur

Research output: Contribution to journalArticle

Abstract

Four groups of women were studied to determine whether low-level antinuclear antibody titers are associated with a higher risk for pregnancy loss. Group A consisted of 30 patients with a history of unexplained fetal losses. Group B consisted of 30 women with "explained" fetal losses (e.g., uterine septum or luteal phase defect). Ages and number of losses were comparable between the women in groups A and B. Group C consisted of 61 healthy pregnant women. Group D involved 61 healthy nonpregnant women of reproductive age. In groups A and B, 40% and 53.3% of the respective patients had antinuclear antibody titers ≥1 : 40. In groups C and D the frequencies of positive antinuclear antibody titers were 8.2% and 5.6%, respectively. This study demonstrates a high prevalence of low-titer antinuclear antibody-positive serum in patients with explained and unexplained pregnancy losses.

Original languageEnglish (US)
Pages (from-to)1493-1497
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume163
Issue number5 PART 1
DOIs
StatePublished - 1990

Fingerprint

Antinuclear Antibodies
Pregnancy
Serum
High-Risk Pregnancy
Luteal Phase
Pregnant Women

Keywords

  • antinuclear antibody
  • habitual abortion
  • Repeated pregnancy wastage or losses

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Antinuclear antibodies in sera of patients with recurrent pregnancy wastage. / Xu, Ling; Chang, Victoria; Murphy, Ana; Rock, John A.; Damewood, Marian; Schlaff, William; Zacur, Howard A.

In: American Journal of Obstetrics and Gynecology, Vol. 163, No. 5 PART 1, 1990, p. 1493-1497.

Research output: Contribution to journalArticle

Xu, Ling ; Chang, Victoria ; Murphy, Ana ; Rock, John A. ; Damewood, Marian ; Schlaff, William ; Zacur, Howard A. / Antinuclear antibodies in sera of patients with recurrent pregnancy wastage. In: American Journal of Obstetrics and Gynecology. 1990 ; Vol. 163, No. 5 PART 1. pp. 1493-1497.
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