Antimicrobial resistance and urinary tract infection recurrence

Caleb P. Nelson, Alejandro Hoberman, Nader Shaikh, Ron Keren, Ranjiv Mathews, Saul P. Greenfield, Tej K. Mattoo, Nathan Gotman, Anastasia Ivanova, Marva Moxey-Mims, Myra A. Carpenter, Russell W. Chesney

Research output: Contribution to journalArticle

Abstract

Background: The Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial found that recurrent urinary tract infections (rUTI) with resistant organisms were more common in the trimethoprim-sulfamethoxazole prophylaxis (TSP) arm. We describe factors associated with trimethoprim-sulfamethoxazole (TMP-SMX) resistance of rUTIs in RIVUR. Methods: Children aged 2 to 71 months with first or second UTI (index UTI) and grade I to IV vesicoureteral reflux (VUR) were randomized to TSP or placebo and followed for 2 years. Factors associated with TMP-SMX-resistant rUTI were evaluated. Results: Among 571 included children, 48% were

Original languageEnglish (US)
JournalPediatrics
Volume137
Issue number4
DOIs
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Nelson, C. P., Hoberman, A., Shaikh, N., Keren, R., Mathews, R., Greenfield, S. P., Mattoo, T. K., Gotman, N., Ivanova, A., Moxey-Mims, M., Carpenter, M. A., & Chesney, R. W. (2016). Antimicrobial resistance and urinary tract infection recurrence. Pediatrics, 137(4). https://doi.org/10.1542/peds.2015-2490