Antimicrobial resistance and urinary tract infection recurrence

Caleb P. Nelson, Alejandro Hoberman, Nader Shaikh, Ron Keren, Ranjiv Mathews, Saul P. Greenfield, Tej K. Mattoo, Nathan Gotman, Anastasia Ivanova, Marva Moxey-Mims, Myra A. Carpenter, Russell W. Chesney

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial found that recurrent urinary tract infections (rUTI) with resistant organisms were more common in the trimethoprim-sulfamethoxazole prophylaxis (TSP) arm. We describe factors associated with trimethoprim-sulfamethoxazole (TMP-SMX) resistance of rUTIs in RIVUR. Methods: Children aged 2 to 71 months with first or second UTI (index UTI) and grade I to IV vesicoureteral reflux (VUR) were randomized to TSP or placebo and followed for 2 years. Factors associated with TMP-SMX-resistant rUTI were evaluated. Results: Among 571 included children, 48% were

Original languageEnglish (US)
JournalPediatrics
Volume137
Issue number4
DOIs
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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