Antimicrobial prophylaxis of travelers’ diarrhea: A selected summary

R. Bradley Sack

Research output: Contribution to journalArticle

Abstract

This paper summarizes the published controlled studies of the prophylaxis of travelers’ diarrhea in which the following drugs have been used: neomycin, nonabsorbable sulfonamides, Streptotriad, doxycycline, erythromycin, and mecillinam. These studies have shown that antimicrobial prophylaxis can be highly effective in preventing episodes of travelers’ diarrhea. The protection, however, lasts only as long as the drugs are being taken; there is no evidence that subclinical infections occur while the drug is being taken. None of the data suggest that antimicrobial prophylaxis increases the probability of infection with drug-resistant enteric pathogens. In these studies few subjects have experienced adverse drug reactions; however, the number of subjects has been too small to allow determination of accurate incidence data. Antimicrobial prophylaxis for travelers’ diarrhea can be effectively and safely used on an individualized basis for persons traveling to areas of high risk.

Original languageEnglish (US)
Pages (from-to)160-166
Number of pages7
JournalReviews of Infectious Diseases
Volume8
DOIs
StatePublished - 1986

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Diarrhea
Pharmaceutical Preparations
Amdinocillin
Asymptomatic Infections
Neomycin
Doxycycline
Sulfonamides
Erythromycin
Drug-Related Side Effects and Adverse Reactions
Incidence
Infection

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Antimicrobial prophylaxis of travelers’ diarrhea : A selected summary. / Sack, R. Bradley.

In: Reviews of Infectious Diseases, Vol. 8, 1986, p. 160-166.

Research output: Contribution to journalArticle

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