Antimicrobial potentiality of the thioxanthene flupenthixol through extensive in vitro and in vivo experiments

L. Jeyaseeli, Asish Das Gupta, K. Asok Kumar, Kaushiki Mazumdar, Noton Kumar Dutta, Sujata G. Dastidar

Research output: Contribution to journalArticle

Abstract

The antipsychotic thioxanthene flupenthixol, possessing a trifluoromethyl substituent at position 2, exhibited a distinct antibacterial property against 352 strains of bacteria from 3 Gram-positive and 13 Gram-negative genera. The minimum inhibitory concentration (MIC) of flupenthixol was determined by the National Committee for Clinical Laboratory Standards agar dilution method. MICs ranged from 10-100 μg/mL in most of the strains, whilst some strains were inhibited at even lower concentrations. The mode of action of this drug was found to be bacteriostatic against Staphylococcus aureus and Vibrio cholerae. In the in vivo experiments, this drug was capable of contributing significant protection (P < 0.001) to a Swiss strain of white mice challenged with 50 median lethal dose of a mouse-virulent strain at a drug concentration of 15 μg/mouse. In addition, flupenthixol remarkably reduced the number of viable bacteria in organ homogenates and blood of mice treated with this drug.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

Keywords

  • Antibacterial activity
  • Antipsychotic
  • Flupenthixol
  • Non-antibiotic
  • Thioxanthene

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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