Antimicrobial effect of furaneol against human pathogenic bacteria and fungi

Woo Sang Sung, Hyun Jun Jung, In Seon Lee, Hyun Soo Kim, Dong Gun Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Furaneol, a key aroma compound found in strawberry, pineapple, and processed foodstuffs, has been known to possess various biological activities on animal models. In this study, the antimicrobial effects of furaneol against human pathogenic microorganisms were investigated. The results indicated that furaneol displayed a broad spectrum of antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi without hemolytic activity on human erythrocyte cells. To confirm the antifungal activity of furaneol, we examined the accumulation of intracellular trehalose as a stress response marker on toxic agents and its effect on dimorphic transition of Candida albicans. The results demonstrated that furaneol induced significant accumulation of intracellular trehalose and exerted its antifungal effecf by disrupting serum-induced mycelial forms. These results suggest that furaneol could be a therapeutic agent having a broad spectrum of antimicrobial activity on human pathogenic microorganisms.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalJournal of Microbiology and Biotechnology
Volume16
Issue number3
StatePublished - Mar 1 2006
Externally publishedYes

Keywords

  • 2,5-dimethyl-4-hydroxy-3(2H)furanone
  • Antimicrobial activity
  • Furaneol
  • Strawberry

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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