Abstract
This study investigates whether a hydrophilic coating (Resist™), designed to inhibit bacterial adherence, applied to inflatable penile prostheses can prolong the effect of intraoperative antibiotics. The activity of antibiotic-soaked Bioflex® (penile prosthetic substrate material) discs with and without Resist™ was examined by measuring the zone of inhibition following in vivo exposure in four groups of rabbits: 1, 2, 3 and 5 days' duration of disc implantation. Coated and uncoated discs were soaked in an aqueous solution of gentamicin and bacitracin. The implanted antibiotic-soaked discs were extracted, and the zone of inhibition against four microorganisms in vitro demonstrated that the Resist™ coating was especially effective against Staphylococcus epidermidis, and statistically significant improvements were observed for the coated over the uncoated substrate up to 3 days following implantation. This effect, and the anti-adherence properties of Resist™, may prevent adhesion and colonization of some microorganisms to penile implants and reduce chances for infection.
Original language | English (US) |
---|---|
Pages (from-to) | 18-21 |
Number of pages | 4 |
Journal | International Journal of Impotence Research |
Volume | 15 |
Issue number | 1 |
DOIs | |
State | Published - 2003 |
Externally published | Yes |
Keywords
- Antibiotics
- Bioflex
- Infection
- Penile prosthesis
ASJC Scopus subject areas
- Urology