TY - JOUR
T1 - Antimetastatic drugs in prostate cancer
AU - Chay, Christopher H.
AU - Cooper, Carlton C.
AU - Hellerstedt, Beth A.
AU - Pienta, Kenneth J.
N1 - Funding Information:
This work was supported by the Special Programs of Research Excellence (SPORE) grant at the University of Michigan Comprehensive Cancer Center (#P50 CA 69568) and Comprehensive Cancer Grant (#P30 CA 46592). Dr Chay is supported by a 2001 American Foundation for Urological Disease Fellowship (Amgen® and PRAECIS Pharmaceuticals, Inc).
PY - 2002/6
Y1 - 2002/6
N2 - Despite the benefits of local therapy with radical prostatectomy and radiation, many patients with prostate cancer require hormonal ablation. While chemotherapy has proven efficacy when the disease progresses to androgen-independent prostate cancer, patients ultimately succumb to the disease, thus the identification of other active therapies is needed. Future treatment modalities include molecular targeted therapies. Prostate cancer has been an ideal model to study the multiple steps required in the metastatic cascade. These steps have been utilized in the development of metastasis inhibitors. This review will present promising agents that have been tested preclinically or are undergoing clinical investigation for their abilities in preventing prostate cancer metastasis. Because prostate cancer metastasizes preferentially to the bone, special attention will be given to agents that interfere with this pattern of metastasis. Specifically, the efficacy of angiogenesis inhibitors, metalloproteinase inhibitors, inhibitors of prostate cancer cell-endothelial cell interactions, and bisphosphonates will be reported. In addition, the introduction of these novel agents has raised many questions as to the relevance and optimal utilization of current clinical trial designs. Issues regarding combination therapy with chemotherapy, optimal timing of treatment with metastatic inhibitors, and the need for surrogate endpoints for molecular targeted therapies will be discussed.
AB - Despite the benefits of local therapy with radical prostatectomy and radiation, many patients with prostate cancer require hormonal ablation. While chemotherapy has proven efficacy when the disease progresses to androgen-independent prostate cancer, patients ultimately succumb to the disease, thus the identification of other active therapies is needed. Future treatment modalities include molecular targeted therapies. Prostate cancer has been an ideal model to study the multiple steps required in the metastatic cascade. These steps have been utilized in the development of metastasis inhibitors. This review will present promising agents that have been tested preclinically or are undergoing clinical investigation for their abilities in preventing prostate cancer metastasis. Because prostate cancer metastasizes preferentially to the bone, special attention will be given to agents that interfere with this pattern of metastasis. Specifically, the efficacy of angiogenesis inhibitors, metalloproteinase inhibitors, inhibitors of prostate cancer cell-endothelial cell interactions, and bisphosphonates will be reported. In addition, the introduction of these novel agents has raised many questions as to the relevance and optimal utilization of current clinical trial designs. Issues regarding combination therapy with chemotherapy, optimal timing of treatment with metastatic inhibitors, and the need for surrogate endpoints for molecular targeted therapies will be discussed.
KW - Angiogenesis inhibitors
KW - Bisphosphonates
KW - Metalloproteinase inhibitors
KW - Metastasis
KW - Prostate cancer
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U2 - 10.3816/CGC.2002.n.002
DO - 10.3816/CGC.2002.n.002
M3 - Review article
C2 - 15046708
AN - SCOPUS:0042383370
SN - 1540-0352
VL - 1
SP - 14
EP - 19
JO - Clinical Prostate Cancer
JF - Clinical Prostate Cancer
IS - 1
ER -