Antimelanogenic activity of 3,4-dihydroxyacetophenone: Inhibition of tyrosinase and MITF

You Jung Kim; Jae Kyung No; Jun Sik Lee; Myoung Soo Kim; Hae Young Chung

doi:10.1271/bbb.70.532

Antimelanogenic activity of 3,4-dihydroxyacetophenone: Inhibition of tyrosinase and MITF

You Jung Kim, Jae Kyung No, Jun Sik Lee, Myoung Soo Kim, Hae Young Chung

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

3,4-Dihydroxyacetophenone (3,4-DHAP) was evaluated for antimelanogenic activity. The tyrosinase inhibitory action by 3,4-DHAP using mushroom tyrosinase revealed a strong inhibitory effect. To further explore this matter, inhibition of tyrosinase and melanin content was measured in B16 melanoma cells (B16 cells). Further, tyrosinase and microphthalmia transcription factor (MITF) protein levels were determined by the Western blot method. Additionally, tyrosinase and MITF protein levels were reduced by 3,4-DHAP. Our data indicate that the antimelanogenic activity of 3,4-DHAP was probably due to its inhibition of tyrosinase activity and the suppression of tyrosinase and MITF protein levels.

Original language	English (US)
Pages (from-to)	532-534
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	70
Issue number	2
DOIs	https://doi.org/10.1271/bbb.70.532
State	Published - 2006
Externally published	Yes

Keywords

3,4-dihydroxyacetophenone
Antimelanogenic activity
Melanin
Microphthalmia transcription factor
Tyrosinase

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "Antimelanogenic activity of 3,4-dihydroxyacetophenone: Inhibition of tyrosinase and MITF",

abstract = "3,4-Dihydroxyacetophenone (3,4-DHAP) was evaluated for antimelanogenic activity. The tyrosinase inhibitory action by 3,4-DHAP using mushroom tyrosinase revealed a strong inhibitory effect. To further explore this matter, inhibition of tyrosinase and melanin content was measured in B16 melanoma cells (B16 cells). Further, tyrosinase and microphthalmia transcription factor (MITF) protein levels were determined by the Western blot method. Additionally, tyrosinase and MITF protein levels were reduced by 3,4-DHAP. Our data indicate that the antimelanogenic activity of 3,4-DHAP was probably due to its inhibition of tyrosinase activity and the suppression of tyrosinase and MITF protein levels.",

keywords = "3,4-dihydroxyacetophenone, Antimelanogenic activity, Melanin, Microphthalmia transcription factor, Tyrosinase",

author = "Kim, {You Jung} and No, {Jae Kyung} and Lee, {Jun Sik} and Kim, {Myoung Soo} and Chung, {Hae Young}",

note = "Funding Information: This work is supported by a grant from the plant Diversity Center, 21st Frontier Research Program, Ministry of Science and Technology (PF0320801-00).",

year = "2006",

doi = "10.1271/bbb.70.532",

language = "English (US)",

volume = "70",

pages = "532--534",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "2",

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TY - JOUR

T1 - Antimelanogenic activity of 3,4-dihydroxyacetophenone

T2 - Inhibition of tyrosinase and MITF

AU - Kim, You Jung

AU - No, Jae Kyung

AU - Lee, Jun Sik

AU - Kim, Myoung Soo

AU - Chung, Hae Young

N1 - Funding Information: This work is supported by a grant from the plant Diversity Center, 21st Frontier Research Program, Ministry of Science and Technology (PF0320801-00).

PY - 2006

Y1 - 2006

N2 - 3,4-Dihydroxyacetophenone (3,4-DHAP) was evaluated for antimelanogenic activity. The tyrosinase inhibitory action by 3,4-DHAP using mushroom tyrosinase revealed a strong inhibitory effect. To further explore this matter, inhibition of tyrosinase and melanin content was measured in B16 melanoma cells (B16 cells). Further, tyrosinase and microphthalmia transcription factor (MITF) protein levels were determined by the Western blot method. Additionally, tyrosinase and MITF protein levels were reduced by 3,4-DHAP. Our data indicate that the antimelanogenic activity of 3,4-DHAP was probably due to its inhibition of tyrosinase activity and the suppression of tyrosinase and MITF protein levels.

AB - 3,4-Dihydroxyacetophenone (3,4-DHAP) was evaluated for antimelanogenic activity. The tyrosinase inhibitory action by 3,4-DHAP using mushroom tyrosinase revealed a strong inhibitory effect. To further explore this matter, inhibition of tyrosinase and melanin content was measured in B16 melanoma cells (B16 cells). Further, tyrosinase and microphthalmia transcription factor (MITF) protein levels were determined by the Western blot method. Additionally, tyrosinase and MITF protein levels were reduced by 3,4-DHAP. Our data indicate that the antimelanogenic activity of 3,4-DHAP was probably due to its inhibition of tyrosinase activity and the suppression of tyrosinase and MITF protein levels.

KW - 3,4-dihydroxyacetophenone

KW - Antimelanogenic activity

KW - Melanin

KW - Microphthalmia transcription factor

KW - Tyrosinase

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U2 - 10.1271/bbb.70.532

DO - 10.1271/bbb.70.532

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AN - SCOPUS:33344454881

SN - 0916-8451

VL - 70

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EP - 534

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 2

ER -

Antimelanogenic activity of 3,4-dihydroxyacetophenone: Inhibition of tyrosinase and MITF

Abstract

Keywords

ASJC Scopus subject areas

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