Antimalarial preclinical drug development: A single oral dose of a 5-carbon-linked trioxane dimer plus mefloquine cures malaria-infected mice

Deuk Kyu Moon; Vandana Singhal; Nirbhay Kumar; Theresa A. Shapiro; Gary H. Posner

doi:10.1002/ddr.20350

Antimalarial preclinical drug development: A single oral dose of a 5-carbon-linked trioxane dimer plus mefloquine cures malaria-infected mice

Deuk Kyu Moon, Vandana Singhal, Nirbhay Kumar, Theresa A. Shapiro, Gary H. Posner

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Three new 5-carbon-linked trioxane dimer carboxylate esters have been prepared from the natural trioxane, artemisinin, in only three steps and 40-50% overall yields. Each one of these new chemical entities is at least as efficacious as the clinically used trioxane antimalarial drug artemether when combined with mefloquine hydrochloride in a low single oral dose cure.

Original language	English (US)
Pages (from-to)	76-81
Number of pages	6
Journal	Drug Development Research
Volume	71
Issue number	1
DOIs	https://doi.org/10.1002/ddr.20350
State	Published - Feb 2010

Keywords

Antimalarial chemotherapy
Artemisinin combination therapy (ACT)
Single oral dose ACT cure
Trioxane dimers

ASJC Scopus subject areas

Drug Discovery

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10.1002/ddr.20350

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keywords = "Antimalarial chemotherapy, Artemisinin combination therapy (ACT), Single oral dose ACT cure, Trioxane dimers",

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AU - Shapiro, Theresa A.

AU - Posner, Gary H.

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Antimalarial preclinical drug development: A single oral dose of a 5-carbon-linked trioxane dimer plus mefloquine cures malaria-infected mice

Abstract

Keywords

ASJC Scopus subject areas

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