Abstract
Three new 5-carbon-linked trioxane dimer carboxylate esters have been prepared from the natural trioxane, artemisinin, in only three steps and 40-50% overall yields. Each one of these new chemical entities is at least as efficacious as the clinically used trioxane antimalarial drug artemether when combined with mefloquine hydrochloride in a low single oral dose cure.
Original language | English (US) |
---|---|
Pages (from-to) | 76-81 |
Number of pages | 6 |
Journal | Drug Development Research |
Volume | 71 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2010 |
Keywords
- Antimalarial chemotherapy
- Artemisinin combination therapy (ACT)
- Single oral dose ACT cure
- Trioxane dimers
ASJC Scopus subject areas
- Drug Discovery