Antimalarial chemotherapy: Artemisinin-derived dimer carbonates and thiocarbonates

Jennifer R. Mazzone, Ryan C. Conyers, Abhai K. Tripathi, David J. Sullivan, Gary H. Posner

Research output: Contribution to journalArticle

Abstract

Several 2-carbon-linked trioxane dimer secondary alcohol carbonates 14 and thiocarbonates 15, combined with mefloquine and administered in a low single oral dose, prolonged the survival times of malaria-infected mice much more effectively than the popular monomeric antimalarial drug artemether plus mefloquine. Three dimer carbonates 14 and one dimer thiocarbonate 15 partially cured malaria-infected mice.

Original languageEnglish (US)
Pages (from-to)2440-2443
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number11
DOIs
StatePublished - Jun 1 2014

Keywords

  • Antimalarial chemotherapy
  • Oral bioavailability
  • Single oral dose ACT
  • Trioxane dimers

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Antimalarial chemotherapy: Artemisinin-derived dimer carbonates and thiocarbonates'. Together they form a unique fingerprint.

  • Cite this