Antimalarial chemotherapeutic peroxides: Artemisinin, yingzhaosu A and related compounds

Kristina Borstnik, Ik Hyeon Paik, Theresa A. Shapiro, Gary H. Posner

Research output: Contribution to journalArticle

Abstract

Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug development for malaria chemotherapy.

Original languageEnglish (US)
Pages (from-to)1661-1667
Number of pages7
JournalInternational Journal for Parasitology
Volume32
Issue number13
DOIs
StatePublished - Dec 4 2002

Keywords

  • Artemisinin
  • Chemotherapy
  • Malaria
  • Plasmodium
  • Rational design of drugs
  • Trioxanes
  • Yingzhaosu A

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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