Antiinflammatory and antiarthritic properties of a substituted quinoline carboxylic acid: CL 306,293

A. E. Sloboda, D. Powell, J. F. Poletto, W. C. Pickett, J. J. Gibbons, D. H. Bell, A. L. Oronsky, S. S. Kerwar

Research output: Contribution to journalArticlepeer-review

Abstract

CL 306,293, a substituted quinoline carboxylic acid at a daily oral dose between 1.5 and 3.0 mg/kg suppressed the inflammation and joint destruction (radiological criteria) associated with both developing and established adjuvant arthritis. When a weekly oral dosing regimen was used, joint destruction was attenuated when this agent was administered at a dose of 50 to 200 mg/kg. Inflammation associated with a delayed type hypersensitivity reaction in dogs was suppressed at a daily oral dose of 0.25 mg/kg or a weekly dose of 1 mg/kg. At efficacious doses, CL 306,293 had no effects on cyclooxygenase or lipoxygenase activities nor did it have an effect on carrageenin induced paw edema. In acute tests, the compound was not ulcerogenic. The above observations indicate that the antiinflammatory effects of CL 306,293 are distinct from those observed with nonsteroidal antiinflammatory agents. Mechanistic studies conducted and to be published indicate that CL 306,293 down regulates T cell function and this mechanism may account, at least in part, for the antiinflammatory and antiarthritic properties observed in animal models of inflammation and joint destruction.

Original languageEnglish (US)
Pages (from-to)855-860
Number of pages6
JournalJournal of Rheumatology
Volume18
Issue number6
StatePublished - Jan 1 1991

Keywords

  • CL 306,293
  • antiinflammatory and antiarthritic properties
  • dog delayed type hypersensitivity
  • rat adjuvant arthritis
  • substituted quinoline carboxylic acid

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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