Antihypertensive use and recurrent falls in community-dwelling older adults: Findings from the health ABC study

For The Health Abc Study

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Despite wide-spread use of antihypertensives in older adults, the literature is unclear about their association with incident recurrent falls over time. Methods. Health, Aging and Body Composition study participants (n = 2,948) who were well functioning at baseline (1997) were followed to Year 7 (2004). The main outcome was recurrent falls (.2) in the ensuing 12 months. Antihypertensive use was examined as: (a) any versus none, (b) long-versus short-term (≥2 vs <2 years), and by (c) summated standardized daily dose (SDD; 1 = maximum recommended daily dose for one antihypertensive), and (d) subclass. Results. Controlling for potential demographic, health status/behavior and access to care confounders, we found no increase in risk of recurrent falls in antihypertensive users compared to nonusers (adjusted odds ratio [AOR] = 1.13; 95% CI = 0.88.1.46), or those taking higher SDDs or for longer durations. Only those using a loop diuretic were found to have a modest increased risk of recurrent falls (AOR = 1.50; 95% CI = 1.11.2.03). Conclusions. Antihypertensive use overall was not statistically significantly associated with recurrent falls after adjusting for important confounders. Loop diuretic use may be associated with recurrent falls and needs further study.

Original languageEnglish (US)
Pages (from-to)1562-1568
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume70
Issue number12
DOIs
StatePublished - 2015

Keywords

  • Drug related
  • Epidemiology
  • Falls
  • Medication

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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