TY - JOUR
T1 - Antihypertensive drug class use and differential risk of urinary incontinence in community-dwelling older women
AU - Peron, Emily P.
AU - Zheng, Yan
AU - Perera, Subashan
AU - Newman, Anne B.
AU - Resnick, Neil M.
AU - Shorr, Ronald I.
AU - Bauer, Douglas C.
AU - Simonsick, Eleanor M.
AU - Gray, Shelly L.
AU - Hanlon, Joseph T.
AU - Ruby, Christine M.
N1 - Funding Information:
Funding This research was supported by the Intramural Research Project of the National Institutes of Health; National Institute on Aging (NIA) Contracts N01-AG-62101, N01-AG-62103, and N01-AG-62106; NIA grants R01-AG-028050, P30-AG-024827, T32-AG-021885, R01-AG-027017, K07-AG-033174, R56-AG-027017, and R01-AG-034056; NINR grant R01-NR-012459; and Agency for Healthcare Research and Quality grants (R01-HS-017695, R01-HS-018721, and K12-HS-019461).
PY - 2012/12
Y1 - 2012/12
N2 - Background.Medication use is a potentially reversible cause of urinary incontinence (UI). The objective of this longitudinal cohort study was to evaluate whether self-reported UI in community-dwelling older women is associated with the use of different classes of antihypertensive agents.Methods.The sample consisted of 959 black and white women aged 72-81 years without baseline (Year 1) UI from the Health, Aging, and Body Composition Study. Use of any antihypertensive from 10 drug classes (ie, alpha blockers [central], alpha blockers [peripheral], angiotensin-converting enzyme inhibitors, angiotensin-II receptor blockers, beta blockers, calcium channel blockers, diuretics [loop], diuretics [potassium-sparing], diuretics [thiazide], and vasodilators) was determined during Year 3 in-person interviews. The number of unique antihypertensive agents used and the standardized daily dosage were also examined. Self-reported UI, operationally defined as leaking urine at least weekly during the previous 12 months, was assessed at Year 4 visits.Results.A total of 197 women (20.5%) reported UI at Year 4. Although any antihypertensive use, number of agents used, and standardized daily dosage at Year 3 were not associated with UI at Year 4, use of one particular drug class-peripheral alpha blockers (ie, doxazosin, prazosin, and terazosin)-was associated with fourfold greater odds of UI (adjusted odds ratio = 4.47; 95% confidence interval = 1.79-11.21; p =. 0014). Further, in post hoc analyses, these odds nearly doubled in those also taking loop diuretics (adjusted odds ratio = 8.81; 95% confidence interval = 1.78-43.53; p =. 0076).Conclusion.In community-dwelling older women, peripheral alpha blocker use was associated with UI, and the odds nearly doubled when used with loop diuretics.
AB - Background.Medication use is a potentially reversible cause of urinary incontinence (UI). The objective of this longitudinal cohort study was to evaluate whether self-reported UI in community-dwelling older women is associated with the use of different classes of antihypertensive agents.Methods.The sample consisted of 959 black and white women aged 72-81 years without baseline (Year 1) UI from the Health, Aging, and Body Composition Study. Use of any antihypertensive from 10 drug classes (ie, alpha blockers [central], alpha blockers [peripheral], angiotensin-converting enzyme inhibitors, angiotensin-II receptor blockers, beta blockers, calcium channel blockers, diuretics [loop], diuretics [potassium-sparing], diuretics [thiazide], and vasodilators) was determined during Year 3 in-person interviews. The number of unique antihypertensive agents used and the standardized daily dosage were also examined. Self-reported UI, operationally defined as leaking urine at least weekly during the previous 12 months, was assessed at Year 4 visits.Results.A total of 197 women (20.5%) reported UI at Year 4. Although any antihypertensive use, number of agents used, and standardized daily dosage at Year 3 were not associated with UI at Year 4, use of one particular drug class-peripheral alpha blockers (ie, doxazosin, prazosin, and terazosin)-was associated with fourfold greater odds of UI (adjusted odds ratio = 4.47; 95% confidence interval = 1.79-11.21; p =. 0014). Further, in post hoc analyses, these odds nearly doubled in those also taking loop diuretics (adjusted odds ratio = 8.81; 95% confidence interval = 1.78-43.53; p =. 0076).Conclusion.In community-dwelling older women, peripheral alpha blocker use was associated with UI, and the odds nearly doubled when used with loop diuretics.
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U2 - 10.1093/gerona/gls177
DO - 10.1093/gerona/gls177
M3 - Article
C2 - 22972942
AN - SCOPUS:84869460783
SN - 1079-5006
VL - 67
SP - 1373
EP - 1378
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 12
ER -