Antigliadin antibodies (AGA IgG) are related to neurochemistry in schizophrenia

Laura M. Rowland, Haley K. Demyanovich, S. Andrea Wijtenburg, William W. Eaton, Katrina Rodriguez, Frank Gaston, Daniela Cihakova, Monica V. Talor, Fang Liu, Robert R. McMahon, L. Elliot Hong, Deanna L. Kelly

Research output: Contribution to journalArticle

Abstract

Inflammation may play a role in schizophrenia; however, subgroups with immune regulation dysfunction may serve as distinct illness phenotypes with potential different treatment and prevention strategies. Emerging data show that about 30% of people with schizophrenia have elevated antigliadin antibodies of the IgG type, representing a possible subgroup of schizophrenia patients with immune involvement. Also, recent data have shown a high correlation of IgG-mediated antibodies between the periphery and cerebral spinal fluid in schizophrenia but not healthy controls, particularly AGA IgG suggesting that these antibodies may be crossing the blood-brain barrier with resulting neuroinflammation. Proton magnetic resonance spectroscopy (MRS) is a non-invasive technique that allows the quantification of certain neurochemicals in vivo thmay proxy inflammation in the brain such as myoinositol and choline-containing compounds (glycerophosphorylcholine and phosphorylcholine). The objective of this exploratory study was to examine the relationship between serum AGA IgG levels and MRS neurochemical levels. We hypothesized that higher AGA IgG levels would be associated with higher levels of myoinositol and choline-containing compounds (glycerophosphorylcholine plus phosphorylcholine GPC + PC) in the anterior cingulate cortex. Thirty-three participants with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder had blood drawn and underwent neuroimaging using MRS within 9 months. We found that 10/33 (30%) had positive AGA IgG (≥20 U) similar to previous findings. While there were no significant differences in myoinositol and GPC + PC levels between patients with and without AGA IgG positivity, there were significant relationships between both myoinositol (r = 0.475, p = 0.007) and GPC + PC (r = 0.36, p = 0.045) with AGA IgG levels. This study shows a possible connection of AGA IgG antibodies to putative brain inflammation as measured by MRS in schizophrenia.

Original languageEnglish (US)
Article number104
JournalFrontiers in Psychiatry
Volume8
Issue numberJUN
DOIs
StatePublished - Jun 19 2017

Fingerprint

Neurochemistry
Schizophrenia
Immunoglobulin G
Antibodies
Inositol
Magnetic Resonance Spectroscopy
Glycerylphosphorylcholine
Phosphorylcholine
Encephalitis
Choline
Gyrus Cinguli
Proxy
Blood-Brain Barrier
Neuroimaging
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Inflammation
Phenotype
Serum
Proton Magnetic Resonance Spectroscopy

Keywords

  • Antibody
  • Gliadin
  • Gluten
  • GPC + PC
  • Inflammation
  • Myoinositol
  • Neuroimaging
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Rowland, L. M., Demyanovich, H. K., Wijtenburg, S. A., Eaton, W. W., Rodriguez, K., Gaston, F., ... Kelly, D. L. (2017). Antigliadin antibodies (AGA IgG) are related to neurochemistry in schizophrenia. Frontiers in Psychiatry, 8(JUN), [104]. DOI: 10.3389/fpsyt.2017.00104

Antigliadin antibodies (AGA IgG) are related to neurochemistry in schizophrenia. / Rowland, Laura M.; Demyanovich, Haley K.; Wijtenburg, S. Andrea; Eaton, William W.; Rodriguez, Katrina; Gaston, Frank; Cihakova, Daniela; Talor, Monica V.; Liu, Fang; McMahon, Robert R.; Hong, L. Elliot; Kelly, Deanna L.

In: Frontiers in Psychiatry, Vol. 8, No. JUN, 104, 19.06.2017.

Research output: Contribution to journalArticle

Rowland, LM, Demyanovich, HK, Wijtenburg, SA, Eaton, WW, Rodriguez, K, Gaston, F, Cihakova, D, Talor, MV, Liu, F, McMahon, RR, Hong, LE & Kelly, DL 2017, 'Antigliadin antibodies (AGA IgG) are related to neurochemistry in schizophrenia' Frontiers in Psychiatry, vol 8, no. JUN, 104. DOI: 10.3389/fpsyt.2017.00104
Rowland LM, Demyanovich HK, Wijtenburg SA, Eaton WW, Rodriguez K, Gaston F et al. Antigliadin antibodies (AGA IgG) are related to neurochemistry in schizophrenia. Frontiers in Psychiatry. 2017 Jun 19;8(JUN). 104. Available from, DOI: 10.3389/fpsyt.2017.00104

Rowland, Laura M.; Demyanovich, Haley K.; Wijtenburg, S. Andrea; Eaton, William W.; Rodriguez, Katrina; Gaston, Frank; Cihakova, Daniela; Talor, Monica V.; Liu, Fang; McMahon, Robert R.; Hong, L. Elliot; Kelly, Deanna L. / Antigliadin antibodies (AGA IgG) are related to neurochemistry in schizophrenia.

In: Frontiers in Psychiatry, Vol. 8, No. JUN, 104, 19.06.2017.

Research output: Contribution to journalArticle

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