Antigens of persistent Chlamydia pneumoniae within coronary atheroma from patients undergoing heart transplantation

Nicole Borel, Andreas Pospischil, Robert D. Dowling, Claudia Dumrese, Charlotte A. Gaydos, Sebastian Bunk, Corinna Hermann, Julio A. Ramirez, James T. Summersgill

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: In order for Chlamydia pneumoniae to play a causative role in chronic human disease, it would need to persist within infected tissue for extended periods of time. Current theory suggests that C pneumoniae may persist at the site of infection via an alternative replicative form, known as an aberrant body. Methods: A panel of C pneumoniae-specific antibodies upregulated by the aberrant body was used to probe tissue specimens from the coronary atheroma from 13 explanted hearts to identify patterns of reactivity in these tissues, as well as to determine the presence and prevalence of C pneumoniae aberrant bodies. Results: Six of 13 patients had an ischaemic cardiomyopathy secondary to coronary atherosclerosis, while another six patients had an idiopathic, dilated cardiomyopathy. One additional patient, a young (24 years) woman with cardiomyopathy, had no history of atherosclerotic disease. Eleven patients were positive by immunohistochemistry with at least one antibody. Coronary arteries of the two other patients were negative by immunohistochemistry with all antibodies. One of these patients was the 24-year-old woman with grade I disease and no risk factors for coronary artery disease. Conclusions: The protein antigens of persistent C pneumoniae infection found in the atheromatous lesions from patients in this study could potentially be used as markers to detect such infections and some may be virulence factors or immunogens specific to C pneumoniae, thus serving as target molecules for diagnostic use or therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalJournal of Clinical Pathology
Volume65
Issue number2
DOIs
StatePublished - Feb 1 2012

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Antigens of persistent Chlamydia pneumoniae within coronary atheroma from patients undergoing heart transplantation'. Together they form a unique fingerprint.

Cite this