Antigenic shift of visna virus in persistently infected sheep

O. Narayan, D. E. Griffin, J. Chase

Research output: Contribution to journalArticlepeer-review

Abstract

Visna viruses isolated from persistently infected sheep were antigenically distinct from the plaque-purified virus used for inoculation. The selection of antigenie variants under antibody pressure, thought to occur in vivo, was reproduced in sheep cell cultures inoculated with plaque-purified visna virus and maintained in antibody. Antigenic shift may be a mechanism for persistence of virus in slow or recurrent viral infections.

Original languageEnglish (US)
Pages (from-to)376-378
Number of pages3
JournalScience
Volume197
Issue number4301
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • General

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