Antigenic shift of visna virus in persistently infected sheep

O. Narayan; D. E. Griffin; J. Chase

doi:10.1126/science.195339

Antigenic shift of visna virus in persistently infected sheep

O. Narayan, D. E. Griffin, J. Chase

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Visna viruses isolated from persistently infected sheep were antigenically distinct from the plaque-purified virus used for inoculation. The selection of antigenie variants under antibody pressure, thought to occur in vivo, was reproduced in sheep cell cultures inoculated with plaque-purified visna virus and maintained in antibody. Antigenic shift may be a mechanism for persistence of virus in slow or recurrent viral infections.

Original language	English (US)
Pages (from-to)	376-378
Number of pages	3
Journal	Science
Volume	197
Issue number	4301
DOIs	https://doi.org/10.1126/science.195339
State	Published - Jan 1 1977

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title = "Antigenic shift of visna virus in persistently infected sheep",

abstract = "Visna viruses isolated from persistently infected sheep were antigenically distinct from the plaque-purified virus used for inoculation. The selection of antigenie variants under antibody pressure, thought to occur in vivo, was reproduced in sheep cell cultures inoculated with plaque-purified visna virus and maintained in antibody. Antigenic shift may be a mechanism for persistence of virus in slow or recurrent viral infections.",

author = "O. Narayan and Griffin, {D. E.} and J. Chase",

year = "1977",

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AU - Griffin, D. E.

AU - Chase, J.

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N2 - Visna viruses isolated from persistently infected sheep were antigenically distinct from the plaque-purified virus used for inoculation. The selection of antigenie variants under antibody pressure, thought to occur in vivo, was reproduced in sheep cell cultures inoculated with plaque-purified visna virus and maintained in antibody. Antigenic shift may be a mechanism for persistence of virus in slow or recurrent viral infections.

AB - Visna viruses isolated from persistently infected sheep were antigenically distinct from the plaque-purified virus used for inoculation. The selection of antigenie variants under antibody pressure, thought to occur in vivo, was reproduced in sheep cell cultures inoculated with plaque-purified visna virus and maintained in antibody. Antigenic shift may be a mechanism for persistence of virus in slow or recurrent viral infections.

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Antigenic shift of visna virus in persistently infected sheep

Abstract

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