Antigenic Determinant(s) Shared by the Human Thy 1 and Human IgG

L. Bonewald, A. C. Wang, I. Y. Wang, C. M. Balch, E. W. Ades

Research output: Contribution to journalArticle

Abstract

A human T cell differentiation antigen (p25) previously described as being the mouse theta equivalent has been examined for shared antigenic determinants with immunoglobulin. A strong cross-reactivity of an antiserum prepared against p25 antigen was established with human IgG subclasses. This antiserum does not react with human IgM or IgA, nor with primate immunoglobulins. The shared determinants appear to be associated with the disulphide-bonded cysteines in the first and third constant domains of the IgG molecule and the 9–112 disulfide bond of Thy 1.

Original languageEnglish (US)
Pages (from-to)428-438
Number of pages11
JournalImmunobiology
Volume166
Issue number4-5
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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