Antigen trapping cells in xenopus laevis

Tissue distribution

William M. Baldwin

Research output: Contribution to journalArticle

Abstract

In the spleen of Xenopus laevis, antigen trapping (XL) cells are located at the periphery of the B-lymphocyte follicles and extend pseudopods through the boundary cell layer into the T-lymphocyte rich marginal zone to provide an anatomical bridge between the B-and T-cell compartments. The relationship between XL cells and nonsplenic antigen trapping cells was probed with a T-"independent" antigen, Aeromonas salmonicida. 125I-Aeromonas were trapped in high concentrations in marrow, spleen and liver. Splenic trapping was most efficient at low doses and liver trapping at high doses of antigen. Immunofluorescence stains demonstrated large cells with trapped Aeromonas in spleen, marrow, liver, thymus, gut, kidney and blood. An antisera to XL cells stained large cells in all of these organs as well as vascular endothelium of the spleen, thymus, gut and lung. Thus, Xenopus has a widely distributed system of antigen trapping cells that may be related to some vascular endothelial cells.

Original languageEnglish (US)
Pages (from-to)709-710
Number of pages2
JournalDevelopmental and Comparative Immunology
Volume7
Issue number4
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Xenopus laevis
Tissue Distribution
Antigens
Spleen
Aeromonas
Thymus Gland
Liver
Bone Marrow
Aeromonas salmonicida
T Independent Antigens
T-Lymphocytes
Computer Communication Networks
Pseudopodia
Vascular Endothelium
Xenopus
Fluorescent Antibody Technique
Immune Sera
B-Lymphocytes
Coloring Agents
Endothelial Cells

ASJC Scopus subject areas

  • Developmental Biology
  • Immunology

Cite this

Antigen trapping cells in xenopus laevis : Tissue distribution. / Baldwin, William M.

In: Developmental and Comparative Immunology, Vol. 7, No. 4, 1983, p. 709-710.

Research output: Contribution to journalArticle

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