Antigen-induced modulation of autonomic and sensory neurons in vitro

Bradley J. Undent, Allen C. Myers, Daniel Weinreich

Research output: Contribution to journalArticle

Abstract

We have addressed the hypothesis that the excitability of peripheral neurons is affected during immediate hypersensitivity reactions. Guinea pigs were actively sensitized to ovalbumin. The electrical membrane properties of neurons within the superior cervical ganglion, bronchial parasympathetic ganglion and nodose gangli on were evaluated before, during and after antigen challenge. In all preparations, antigen stimulation induced the release of histamine and arachidonic acid metabolites. Our results support the hypothesis that the excitability of sympathetic, parasympathetic and sensory C-type neurons may be increased during immediate hypersensitivity reactions.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume94
Issue number1-4
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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