Antifungal effect of amentoflavone derived from Selaginella tamariscina

Jun Jung Hyun; Sang Sung Woo; Soo Hwan Yeo; Soo Kim Hyun; In Seon Lee; Eun Rhan Woo; Gun Lee Dong

doi:10.1007/bf02974074

Antifungal effect of amentoflavone derived from Selaginella tamariscina

Jun Jung Hyun, Sang Sung Woo, Soo Hwan Yeo, Soo Kim Hyun, In Seon Lee, Eun Rhan Woo, Gun Lee Dong

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Amentoflavone is a plant biflavonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.

Original language	English (US)
Pages (from-to)	746-751
Number of pages	6
Journal	Archives of Pharmacal Research
Volume	29
Issue number	9
DOIs	https://doi.org/10.1007/bf02974074
State	Published - Sep 30 2006
Externally published	Yes

Keywords

Amentoflavone
Antifungal activity
Biflavonoid
Dimorphic transition

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/bf02974074

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title = "Antifungal effect of amentoflavone derived from Selaginella tamariscina",

abstract = "Amentoflavone is a plant biflavonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.",

keywords = "Amentoflavone, Antifungal activity, Biflavonoid, Dimorphic transition",

author = "Hyun, {Jun Jung} and Woo, {Sang Sung} and Yeo, {Soo Hwan} and Hyun, {Soo Kim} and Lee, {In Seon} and Woo, {Eun Rhan} and Dong, {Gun Lee}",

note = "Funding Information: This work was supported by Ministry of Science & Technology (MOST) and the Korea Science and Engineering Foundation (KOSEF) through the Center for Traditional Microorganism Resources (TMR) at Keimyung University.",

year = "2006",

month = sep,

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doi = "10.1007/bf02974074",

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T1 - Antifungal effect of amentoflavone derived from Selaginella tamariscina

AU - Hyun, Jun Jung

AU - Woo, Sang Sung

AU - Yeo, Soo Hwan

AU - Hyun, Soo Kim

AU - Lee, In Seon

AU - Woo, Eun Rhan

AU - Dong, Gun Lee

N1 - Funding Information: This work was supported by Ministry of Science & Technology (MOST) and the Korea Science and Engineering Foundation (KOSEF) through the Center for Traditional Microorganism Resources (TMR) at Keimyung University.

PY - 2006/9/30

Y1 - 2006/9/30

N2 - Amentoflavone is a plant biflavonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.

AB - Amentoflavone is a plant biflavonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.

KW - Amentoflavone

KW - Antifungal activity

KW - Biflavonoid

KW - Dimorphic transition

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IS - 9

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Antifungal effect of amentoflavone derived from Selaginella tamariscina

Abstract

Keywords

ASJC Scopus subject areas

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