Antifungal effect of amentoflavone derived from Selaginella tamariscina

Jun Jung Hyun, Sang Sung Woo, Soo Hwan Yeo, Soo Kim Hyun, In Seon Lee, Eun Rhan Woo, Gun Lee Dong

Research output: Contribution to journalArticlepeer-review

Abstract

Amentoflavone is a plant biflavonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.

Original languageEnglish (US)
Pages (from-to)746-751
Number of pages6
JournalArchives of Pharmacal Research
Volume29
Issue number9
DOIs
StatePublished - Sep 30 2006
Externally publishedYes

Keywords

  • Amentoflavone
  • Antifungal activity
  • Biflavonoid
  • Dimorphic transition

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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