TY - JOUR
T1 - Antifungal activity of 2,3-diphenyl-2,3-dihydro-1,3-thiaza-4-ones against two human pathogenic fungi
AU - Liporagi-Lopes, Livia
AU - Sobhi, Hany F.
AU - Silverberg, Lee J.
AU - Cordero, Radames J.B.
AU - Casadevall, Arturo
N1 - Publisher Copyright:
The copyright holder for this preprint is the author/funder,who has granted biorxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/27
Y1 - 2020/6/27
N2 - Invasive fungal diseases are prevalent in immunocompromised individuals in whom current therapies often provide suboptimal results. Additionally, the increased resistance to the available antifungal drugs necessitates a search for new compounds. This study reports the antifungal activity of six 5-, 6-, and 7-membered 2,3-diphenyl-2,3-dihydro-1,3-thiaza-4-ones against Lomentospora prolificans and Cryptococcus neoformans. Our data showed that some of the compounds tested had a low MIC and damage on the cell surface of the tested fungal species.
AB - Invasive fungal diseases are prevalent in immunocompromised individuals in whom current therapies often provide suboptimal results. Additionally, the increased resistance to the available antifungal drugs necessitates a search for new compounds. This study reports the antifungal activity of six 5-, 6-, and 7-membered 2,3-diphenyl-2,3-dihydro-1,3-thiaza-4-ones against Lomentospora prolificans and Cryptococcus neoformans. Our data showed that some of the compounds tested had a low MIC and damage on the cell surface of the tested fungal species.
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U2 - 10.1101/2020.06.27.175711
DO - 10.1101/2020.06.27.175711
M3 - Article
AN - SCOPUS:85098903616
JO - Advances in Water Resources
JF - Advances in Water Resources
SN - 0309-1708
ER -