Antifungal activities of natural and synthetic iron chelators alone and in combination with azole and polyene antibiotics against Aspergillus fumigatus

Kol A. Zarember, Anna R. Cruz, Chiung Yu Huang, John I. Gallin

Research output: Contribution to journalArticlepeer-review

Abstract

Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy against conidia was observed for combinations of ketoconazole with ciclopirox or deferiprone, lactoferrin with amphotericin B, and fluconazole with deferiprone. Iron chelation alone or combined with antifungal drugs may be useful for prevention and treatment of mycosis.

Original languageEnglish (US)
Pages (from-to)2654-2656
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume53
Issue number6
DOIs
StatePublished - Jun 2009

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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