Antiepileptics

Brian Spoelhof, Lynn Frendak, Lucia Rivera Lara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The Side Effects of Drugs Annuals is a series of volumes in which the adverse effects and reactions of medications are analyzed. The series supplements the contents of Meyler's Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions. This review of the 2013-2014 publications on antiepileptic drugs covers brivaracetam, carbamazepine, eslicarbazepine, ethosuximide, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, perampanel, phenobarbital and primidone, phenytoin and fosphenytoin, pregabalin, retigabine (ezogabine), rufinamide, topiramate, valproate sodium and semisodium (divalproex), vigabatrin, and zonisamide. Antiepileptic drugs often interact with other medications through multiple mechanisms including CYP P450 induction and inhibition. There is a special review on pharmacogenomics and the link between certain genetic aberrations and the propensity to develop adverse effects to antiepileptic medications, including CYP P450 metabolism. Specific genetic polymorphisms have been associated with psychiatric symptoms in patients taking levetiracetam, liver failure in patients taking valproic acid, neurologic side effects in patients taking carbamazepine, and an increased risk of severe cutaneous reactions in patients taking carbamazepine, lamotrigine, phenytoin, and phenobarbital.

Original languageEnglish (US)
Title of host publicationA worldwide yearly survey of new data in adverse drug reactions, 2015
EditorsSidhartha D. Ray
PublisherElsevier
Pages85-106
Number of pages22
ISBN (Print)9780444635259
DOIs
StatePublished - Jan 1 2015

Publication series

NameSide Effects of Drugs Annual
Volume37
ISSN (Print)0378-6080

Keywords

  • Adverse drug reactions
  • Antiepileptics
  • Drug-drug interactions
  • Pharmacogenomics
  • Seizure disorder
  • Teratogenicity
  • Toxicity

ASJC Scopus subject areas

  • Pharmacology
  • Drug guides
  • Pharmacology (medical)

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  • Cite this

    Spoelhof, B., Frendak, L., & Lara, L. R. (2015). Antiepileptics. In S. D. Ray (Ed.), A worldwide yearly survey of new data in adverse drug reactions, 2015 (pp. 85-106). (Side Effects of Drugs Annual; Vol. 37). Elsevier. https://doi.org/10.1016/bs.seda.2015.06.008