Antiepileptic drugs modify power of high EEG frequencies and their neural generators

S. Arzy, G. Allali, D. Brunet, C. M. Michel, Peter W Kaplan, M. Seeck

Research output: Contribution to journalArticle

Abstract

Background: The clinical and molecular effects of antiepileptic drugs (AEDs) have been extensively investigated. Much less is known about their effects on human electrophysiology. Methods: Topographic analysis in the frequency domain has been used to analyze 104 electroencephalogram (EEG) epochs of 52 patients presenting with first-ever generalized seizure, with normal MRI and EEG. Patients were treated with valproate, carbamazepine, or lamotrigine in monotherapy (each group n = 13). Thirteen patients without medication served as a control group. Results: Carbamazepine and lamotrigine, both sodium-channel modulators, altered brain topography in the gamma range in the same frequency bands (50-60 Hz). Valproate, which has multiple actions on sodium and calcium channels as well as GABA turnover, modified brain topography in the low gamma range (30-40 Hz). No such changes were found in the control group. For all AEDs, the neural generators were shifted more anteriorly in medial temporal through to inferior frontal regions. Conclusion: Decreased gamma-power and anterior shift of neural generators after AED introduction reflect AED influence on human electrophysiology.

Original languageEnglish (US)
Pages (from-to)1308-1312
Number of pages5
JournalEuropean Journal of Neurology
Volume17
Issue number10
DOIs
StatePublished - Oct 2010

Fingerprint

Anticonvulsants
Electroencephalography
Sodium Channels
Electrophysiology
Carbamazepine
Valproic Acid
Control Groups
Brain
Calcium Channels
gamma-Aminobutyric Acid
Seizures
lamotrigine

Keywords

  • anterior temporal cortex
  • antiepileptic drugs
  • gamma band
  • inferior frontal cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Antiepileptic drugs modify power of high EEG frequencies and their neural generators. / Arzy, S.; Allali, G.; Brunet, D.; Michel, C. M.; Kaplan, Peter W; Seeck, M.

In: European Journal of Neurology, Vol. 17, No. 10, 10.2010, p. 1308-1312.

Research output: Contribution to journalArticle

Arzy, S. ; Allali, G. ; Brunet, D. ; Michel, C. M. ; Kaplan, Peter W ; Seeck, M. / Antiepileptic drugs modify power of high EEG frequencies and their neural generators. In: European Journal of Neurology. 2010 ; Vol. 17, No. 10. pp. 1308-1312.
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