Antiepileptic drugs in Posttraumatic Stress Disorder

Iulian Iancu, Yitzhak Rosen, Kotler Moshe

Research output: Contribution to journalArticlepeer-review

Abstract

Antiepileptic drugs might be effective in the treatment of patients with Posttraumatic Stress Disorder, a condition with unmet pharmacologic needs. We review the literature on the efficacy and tolerability of antiepileptic drugs in Posttraumatic Stress Disorder, both case reports and open studies, as well as controlled studies if available. The results of the studies will be presented together with their methodological limitations (e.g., open trials, use of additional medications, and lack of use of standardized scales for Posttraumatic Stress Disorder). The effects of antiepileptic drugs on kindling, a suggested pathogenesis for Posttraumatic Stress Disorder are overviewed, and suggestions for further research are raised.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalClinical neuropharmacology
Volume25
Issue number4
DOIs
StatePublished - Aug 12 2002
Externally publishedYes

Keywords

  • Antiepileptic drugs
  • Controlled studies
  • Kindling
  • Posttraumatic stress disorder
  • Tolerability

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

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