ANTIEMETICS: NEUROTRANSMITTER RECEPTOR BINDING PREDICTS THERAPEUTIC ACTIONS

Stephen J. Peroutka, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Neurotransmitter receptor binding studies indicate that effective antiemetic drugs potently block histamine H1, muscarinic cholinergic, or dopamine D2 receptors. Drug combinations affecting more than one of these receptors appear more clinically efficacious. Designing individual drugs or combinations that influence these three receptors may provide improved emesis control.

Original languageEnglish (US)
Pages (from-to)658-659
Number of pages2
JournalThe Lancet
Volume319
Issue number8273
DOIs
StatePublished - Mar 20 1982

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this