Antiemetic Effect of Dexamethasone

B. Uzzan; A. Chapman; Thomas F. Paine; Maurie Markman; Vivian Sheidler; David S. Ettinger; Shirley A. Quaskey; E. David Mellits

doi:10.1056/NEJM198412133112415

Antiemetic Effect of Dexamethasone

B. Uzzan, A. Chapman, Thomas F. Paine, Maurie Markman, Vivian Sheidler, David S. Ettinger, Shirley A. Quaskey, E. David Mellits

School of Medicine

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: Markman et al. showed in a randomized double-blind controlled trial that dexamethasone had a significantly greater antiemetic effect than prochlorperazine in outpatients receiving cancer chemotherapy (Aug. 30 issue).¹ The authors used a crossover design for their study, but they do not specify the method they used to determine randomly the order of administration of the two drugs. Even assuming an initially balanced assignment between patients receiving dexamethasone first and those receiving prochlorperazine first, an imbalanced distribution in the group of seven patients who dropped out of the study may have introduced a bias. Patients may have experienced…

Original language	English (US)
Pages (from-to)	1576-1577
Number of pages	2
Journal	New England Journal of Medicine
Volume	311
Issue number	24
DOIs	https://doi.org/10.1056/NEJM198412133112415
State	Published - Dec 13 1984

ASJC Scopus subject areas

General Medicine

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title = "Antiemetic Effect of Dexamethasone",

abstract = "To the Editor: Markman et al. showed in a randomized double-blind controlled trial that dexamethasone had a significantly greater antiemetic effect than prochlorperazine in outpatients receiving cancer chemotherapy (Aug. 30 issue).1 The authors used a crossover design for their study, but they do not specify the method they used to determine randomly the order of administration of the two drugs. Even assuming an initially balanced assignment between patients receiving dexamethasone first and those receiving prochlorperazine first, an imbalanced distribution in the group of seven patients who dropped out of the study may have introduced a bias. Patients may have experienced…",

author = "B. Uzzan and A. Chapman and Paine, {Thomas F.} and Maurie Markman and Vivian Sheidler and Ettinger, {David S.} and Quaskey, {Shirley A.} and Mellits, {E. David}",

year = "1984",

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doi = "10.1056/NEJM198412133112415",

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AU - Uzzan, B.

AU - Chapman, A.

AU - Paine, Thomas F.

AU - Markman, Maurie

AU - Sheidler, Vivian

AU - Ettinger, David S.

AU - Quaskey, Shirley A.

AU - Mellits, E. David

PY - 1984/12/13

Y1 - 1984/12/13

N2 - To the Editor: Markman et al. showed in a randomized double-blind controlled trial that dexamethasone had a significantly greater antiemetic effect than prochlorperazine in outpatients receiving cancer chemotherapy (Aug. 30 issue).1 The authors used a crossover design for their study, but they do not specify the method they used to determine randomly the order of administration of the two drugs. Even assuming an initially balanced assignment between patients receiving dexamethasone first and those receiving prochlorperazine first, an imbalanced distribution in the group of seven patients who dropped out of the study may have introduced a bias. Patients may have experienced…

AB - To the Editor: Markman et al. showed in a randomized double-blind controlled trial that dexamethasone had a significantly greater antiemetic effect than prochlorperazine in outpatients receiving cancer chemotherapy (Aug. 30 issue).1 The authors used a crossover design for their study, but they do not specify the method they used to determine randomly the order of administration of the two drugs. Even assuming an initially balanced assignment between patients receiving dexamethasone first and those receiving prochlorperazine first, an imbalanced distribution in the group of seven patients who dropped out of the study may have introduced a bias. Patients may have experienced…

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Antiemetic Effect of Dexamethasone

Abstract

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