Antidiarrheal effects of L-histidine-supplemented rice-based oral rehydration solution in the treatment of male adults with severe cholera in Bangladesh: A double-blind, randomized trial

Golam H. Rabbani, David A. Sack, Shamsir Ahmed, Johnny W. Peterson, Shyamal K. Saha, Farzana Marni, Peter Thomas

Research output: Contribution to journalArticle

Abstract

Background. Because of the antisecretory potential of L-histidine in the intestinal tract, its antidiarrheal effects were determined in cholera. Methods. In a double-blind trial of 126 adult male patients with cholera, L-histidine (2.5 g/L) was mixed with a rice-based oral rehydration solution (ORS) and administered to 62 patients; 64 patients received the same ORS without L-histidine. All patients received ciprofloxacin at a dosage of 500 mg every 12 h for 72 h. Fluid output (of stool, urine, and vomit) and intake (of ORS, water, and intravenous fluid) were determined every 8 h for 72 h. Results. Administration of ORS with L-histidine significantly (P.05]). Administration of ORS with L-histidine also significantly reduced (P

Original languageEnglish (US)
Pages (from-to)1507-1514
Number of pages8
JournalJournal of Infectious Diseases
Volume191
Issue number9
DOIs
StatePublished - May 1 2005
Externally publishedYes

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Rehydration Solutions
Antidiarrheals
Bangladesh
Cholera
Fluid Therapy
Histidine
Therapeutics
Ciprofloxacin
Oryza
Urine
Water

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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Antidiarrheal effects of L-histidine-supplemented rice-based oral rehydration solution in the treatment of male adults with severe cholera in Bangladesh : A double-blind, randomized trial. / Rabbani, Golam H.; Sack, David A.; Ahmed, Shamsir; Peterson, Johnny W.; Saha, Shyamal K.; Marni, Farzana; Thomas, Peter.

In: Journal of Infectious Diseases, Vol. 191, No. 9, 01.05.2005, p. 1507-1514.

Research output: Contribution to journalArticle

Rabbani, Golam H. ; Sack, David A. ; Ahmed, Shamsir ; Peterson, Johnny W. ; Saha, Shyamal K. ; Marni, Farzana ; Thomas, Peter. / Antidiarrheal effects of L-histidine-supplemented rice-based oral rehydration solution in the treatment of male adults with severe cholera in Bangladesh : A double-blind, randomized trial. In: Journal of Infectious Diseases. 2005 ; Vol. 191, No. 9. pp. 1507-1514.
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