Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice

Soichiro Ide, Shunsuke Fujiwara, Masayuki Fujiwara, Ichiro Sora, Kazutaka Ikeda, Masabumi Minami, George R. Uhl, Kumatoshi Ishihara

Research output: Contribution to journalArticlepeer-review

Abstract

Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO) mice. Venlafaxine reduced immobility time in wildtype mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressantlike effects of venlafaxine.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalJournal of Pharmacological Sciences
Volume114
Issue number1
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • μ-opioid receptor
  • Antidepressant
  • Knockout mouse

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

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