Anticipation in the rodent head direction system can be explained by an interaction of head movements and vestibular firing properties

Matthijs A A Van Der Meer, James Knierim, D. Yoganarasimha, Emma R. Wood, Mark C W Van Rossum

Research output: Contribution to journalArticle

Abstract

The rodent head-direction (HD) system, which codes for the animal's head direction in the horizontal plane, is thought to be critically involved in spatial navigation. Electrophysiological recording studies have shown that HD cells can anticipate the animal's HD by up to 75-80 ms. The origin of this anticipation is poorly understood. In this modeling study, we provide a novel explanation for HD anticipation that relies on the firing properties of neurons afferent to the HD system. By incorporating spike rate adaptation and postinhibitory rebound as observed in medial vestibular nucleus neurons, our model produces realistic anticipation on a large corpus of rat movement data. In addition, HD anticipation varies between recording sessions of the same cell, between active and passive movement, and between different studies. Such differences do not appear to be correlated with behavioral variables and cannot be accounted for using earlier models. In the present model, anticipation depends on the power spectrum of the head movements. By direct comparison with recording data, we show that the model explains 60-80% of the observed anticipation variability. We conclude that HD afferent dynamics and the statistics of rat head movements are important in generating HD anticipation. This result contributes to understanding the functional circuitry of the HD system and has methodological implications for studies of HD anticipation.

Original languageEnglish (US)
Pages (from-to)1883-1897
Number of pages15
JournalJournal of Neurophysiology
Volume98
Issue number4
DOIs
StatePublished - Oct 2007
Externally publishedYes

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Head Movements
Rodentia
Head
Direction compound
Vestibular Nuclei
Afferent Neurons

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Anticipation in the rodent head direction system can be explained by an interaction of head movements and vestibular firing properties. / Van Der Meer, Matthijs A A; Knierim, James; Yoganarasimha, D.; Wood, Emma R.; Van Rossum, Mark C W.

In: Journal of Neurophysiology, Vol. 98, No. 4, 10.2007, p. 1883-1897.

Research output: Contribution to journalArticle

Van Der Meer, Matthijs A A ; Knierim, James ; Yoganarasimha, D. ; Wood, Emma R. ; Van Rossum, Mark C W. / Anticipation in the rodent head direction system can be explained by an interaction of head movements and vestibular firing properties. In: Journal of Neurophysiology. 2007 ; Vol. 98, No. 4. pp. 1883-1897.
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