Antibrain antibodies in children with autism and their unaffected siblings

Harvey S. Singer, Christina M. Morris, Phillip N. Williams, Dustin Y. Yoon, John J. Hong, Andrew W. Zimmerman

Research output: Contribution to journalArticlepeer-review

Abstract

Serum autoantibodies to human brain, identified by ELISA and Western immunoblotting, were evaluated in 29 children with autism spectrum disorder (22 with autistic disorder), 9 non-autistic siblings and 13 controls. More autistic subjects than controls had bands at 100 kDa in caudate, putamen and prefrontal cortex (p < 0.01) as well as larger peak heights of bands at 73 kDa in the cerebellum and cingulate gyrus. Both autistic disorder subjects and their matched non-autistic siblings had denser bands (peak height and/or area under the curve) at 73 kDa in the cerebellum and cingulate gyrus than did controls (p < 0.01). Results suggest that children with autistic disorder and their siblings exhibit differences compared to controls in autoimmune reactivity to specific epitopes located in distinct brain regions.

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalJournal of Neuroimmunology
Volume178
Issue number1-2
DOIs
StatePublished - Sep 2006

Keywords

  • 100 kDa
  • 73 kDa
  • Autism
  • Autoantibodies
  • Immunoblotting
  • Siblings

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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